Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI055848-02
Application #
6767636
Study Section
Immunological Sciences Study Section (IMS)
Program Officer
Dong, Gang
Project Start
2003-07-01
Project End
2007-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
2
Fiscal Year
2004
Total Cost
$273,710
Indirect Cost
Name
University of Cincinnati
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
041064767
City
Cincinnati
State
OH
Country
United States
Zip Code
45221
Phelan, James D; Orekov, Tatyana; Finkelman, Fred D (2008) Cutting edge: mechanism of enhancement of in vivo cytokine effects by anti-cytokine monoclonal antibodies. J Immunol 180:44-8
Khodoun, Marat; Lewis, Christina C; Lewis, Christina et al. (2007) Differences in expression, affinity, and function of soluble (s)IL-4Ralpha and sIL-13Ralpha2 suggest opposite effects on allergic responses. J Immunol 179:6429-38
Perkins, Charles; Wills-Karp, Marsha; Finkelman, Fred D (2006) IL-4 induces IL-13-independent allergic airway inflammation. J Allergy Clin Immunol 118:410-9
West, Erin E; Lavoie, Tera L; Orens, Jonathan B et al. (2006) Pluripotent allospecific CD8+ effector T cells traffic to lung in murine obliterative airway disease. Am J Respir Cell Mol Biol 34:108-18
Morris, Suzanne C; Orekhova, Tatyana; Meadows, Michelle J et al. (2006) IL-4 induces in vivo production of IFN-gamma by NK and NKT cells. J Immunol 176:5299-305
Finkelman, Fred D; Yang, Mingyan; Perkins, Charles et al. (2005) Suppressive effect of IL-4 on IL-13-induced genes in mouse lung. J Immunol 174:4630-8
Liu, Zhugong; Liu, Qian; Hamed, Hossein et al. (2005) IL-2 and autocrine IL-4 drive the in vivo development of antigen-specific Th2 T cells elicited by nematode parasites. J Immunol 174:2242-9
Khodoun, Marat V; Orekhova, Tatyana; Potter, Crystal et al. (2004) Basophils initiate IL-4 production during a memory T-dependent response. J Exp Med 200:857-70