Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI056156-02
Application #
6756002
Study Section
Immunobiology Study Section (IMB)
Program Officer
Mallia, Conrad M
Project Start
2003-06-15
Project End
2007-11-30
Budget Start
2003-12-01
Budget End
2004-11-30
Support Year
2
Fiscal Year
2004
Total Cost
$346,500
Indirect Cost
Name
Duke University
Department
Neurosciences
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Zhu, Minghua; Fuller, Deirdre M; Ou-Yang, Chih-wen et al. (2012) Tyrosine phosphorylation-independent regulation of lipopolysaccharide-mediated response by the transmembrane adaptor protein LAB. J Immunol 188:2733-41
Fuller, Deirdre M; Zhu, Minghua; Song, Xiaohua et al. (2012) Regulation of RasGRP1 function in T cell development and activation by its unique tail domain. PLoS One 7:e38796
Fuller, Deirdre M; Zhu, Minghua; Koonpaew, Surapong et al. (2012) The importance of the Erk pathway in the development of linker for activation of T cells-mediated autoimmunity. J Immunol 189:4005-13
Ou-Yang, Chih-wen; Zhu, Minghua; Fuller, Deirdre M et al. (2012) Role of LAT in the granule-mediated cytotoxicity of CD8 T cells. Mol Cell Biol 32:2674-84
Zhu, Minghua; Fuller, Deirdre M; Zhang, Weiguo (2012) The role of Ras guanine nucleotide releasing protein 4 in Fc epsilonRI-mediated signaling, mast cell function, and T cell development. J Biol Chem 287:8135-43
Markegard, Evan; Trager, Evan; Yang, Chih-wen Ou et al. (2011) Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCR? gene expression. PLoS One 6:e25540
Fuller, Deirdre M; Zhu, Minghua; Ou-Yang, Chih-Wen et al. (2011) A tale of two TRAPs: LAT and LAB in the regulation of lymphocyte development, activation, and autoimmunity. Immunol Res 49:97-108
Shen, Shudan; Chuck, Mariana I; Zhu, Minghua et al. (2010) The importance of LAT in the activation, homeostasis, and regulatory function of T cells. J Biol Chem 285:35393-405
Whittaker, Gillian C; Orr, Selinda J; Quigley, Laura et al. (2010) The linker for activation of B cells (LAB)/non-T cell activation linker (NTAL) regulates triggering receptor expressed on myeloid cells (TREM)-2 signaling and macrophage inflammatory responses independently of the linker for activation of T cells. J Biol Chem 285:2976-85
Kambayashi, Taku; Okumura, Mariko; Baker, Rebecca G et al. (2010) Independent and cooperative roles of adaptor molecules in proximal signaling during FcepsilonRI-mediated mast cell activation. Mol Cell Biol 30:4188-96

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