Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI056177-02
Application #
6765902
Study Section
Special Emphasis Panel (ZRG1-BM-1 (01))
Program Officer
Van de Verg, Lillian L
Project Start
2003-07-01
Project End
2007-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
2
Fiscal Year
2004
Total Cost
$404,230
Indirect Cost

  Institution

Name
University of Pittsburgh
Department
Genetics
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213

  Publications

Garcia, J P; Giannitti, F; Finnie, J W et al. (2015) Comparative neuropathology of ovine enterotoxemia produced by Clostridium perfringens type D wild-type strain CN1020 and its genetically modified derivatives. Vet Pathol 52:465-75
Ma, Menglin; Li, Jihong; McClane, Bruce A (2015) Structure-function analysis of peptide signaling in the Clostridium perfringens Agr-like quorum sensing system. J Bacteriol 197:1807-18
Li, Jihong; Freedman, John C; McClane, Bruce A (2015) NanI Sialidase, CcpA, and CodY Work Together To Regulate Epsilon Toxin Production by Clostridium perfringens Type D Strain CN3718. J Bacteriol 197:3339-53
Chen, Jianming; McClane, Bruce A (2015) Characterization of Clostridium perfringens TpeL toxin gene carriage, production, cytotoxic contributions, and trypsin sensitivity. Infect Immun 83:2369-81
Uzal, Francisco A; McClane, Bruce A; Cheung, Jackie K et al. (2015) Animal models to study the pathogenesis of human and animal Clostridium perfringens infections. Vet Microbiol 179:23-33
Theoret, James R; Uzal, Francisco A; McClane, Bruce A (2015) Identification and characterization of Clostridium perfringens beta toxin variants with differing trypsin sensitivity and in vitro cytotoxicity activity. Infect Immun 83:1477-86
Freedman, John C; Theoret, James R; Wisniewski, Jessica A et al. (2015) Clostridium perfringens type A-E toxin plasmids. Res Microbiol 166:264-79
Li, Jihong; McClane, Bruce A (2014) The Sialidases of Clostridium perfringens type D strain CN3718 differ in their properties and sensitivities to inhibitors. Appl Environ Microbiol 80:1701-9
Freedman, John C; Li, Jihong; Uzal, Francisco A et al. (2014) Proteolytic processing and activation of Clostridium perfringens epsilon toxin by caprine small intestinal contents. MBio 5:e01994-14
Uzal, Francisco A; Freedman, John C; Shrestha, Archana et al. (2014) Towards an understanding of the role of Clostridium perfringens toxins in human and animal disease. Future Microbiol 9:361-77

Showing the most recent 10 out of 64 publications