The goal of this proposed research is to develop and understand a new, very rapid, and highly efficient method for identifying and characterizing bacteria and other microorganisms. This type of analysis could be performed in minutes to seconds rather than the hours to days time-scale currently needed. Several microbes could be analyzed, characterized, and quantitated simultaneously. This is not possible with any current approach, or even combinations of approaches. Furthermore, since the proposed project is based on a separations technique, it is not as vulnerable to false positive and false negative results caused by the presence of contaminants. This has important implications for: a) the rapid and accurate diagnosis of some diseases, b) rapidly screening cell-molecule interactions as a way to identify new drugs, and c) rapidly characterizing microbes for biotech applications or bioterrorism identification. Understanding the mechanism of this important microbial separation process is imperative if we are to be able to develop and use it optimally. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
1R01AI056238-01
Application #
6672241
Study Section
Special Emphasis Panel (ZRG1-BECM (01))
Program Officer
Hall, Robert H
Project Start
2003-09-30
Project End
2006-01-31
Budget Start
2003-09-30
Budget End
2004-01-31
Support Year
1
Fiscal Year
2003
Total Cost
$65,640
Indirect Cost
Name
Iowa State University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
005309844
City
Ames
State
IA
Country
United States
Zip Code
50011