Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI057029-02
Application #
6768759
Study Section
Special Emphasis Panel (ZRG1-VACC (01))
Program Officer
Pensiero, Michael N
Project Start
2003-07-01
Project End
2007-10-31
Budget Start
2003-11-01
Budget End
2004-10-31
Support Year
2
Fiscal Year
2004
Total Cost
$629,365
Indirect Cost
Name
Emory University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Kwa, Suefen; Lai, Lilin; Gangadhara, Sailaja et al. (2014) CD40L-adjuvanted DNA/modified vaccinia virus Ankara simian immunodeficiency virus SIV239 vaccine enhances SIV-specific humoral and cellular immunity and improves protection against a heterologous SIVE660 mucosal challenge. J Virol 88:9579-89
Nigam, Pragati; Kwa, Suefen; Velu, Vijayakumar et al. (2011) Loss of IL-17-producing CD8 T cells during late chronic stage of pathogenic simian immunodeficiency virus infection. J Immunol 186:745-53
Kwa, Suefen; Kannanganat, Sunil; Nigam, Pragati et al. (2011) Plasmacytoid dendritic cells are recruited to the colorectum and contribute to immune activation during pathogenic SIV infection in rhesus macaques. Blood 118:2763-73
Ganguly, S; Manicassamy, S; Blackwell, J et al. (2011) Adenovirus type 5 induces vitamin A-metabolizing enzymes in dendritic cells and enhances priming of gut-homing CD8 T cells. Mucosal Immunol 4:528-38
Pillai, Vinod Kumar Bhaskara; Kannanganat, Sunil; Penaloza-Macmaster, Pablo et al. (2011) Different patterns of expansion, contraction and memory differentiation of HIV-1 Gag-specific CD8 T cells elicited by adenovirus type 5 and modified vaccinia Ankara vaccines. Vaccine 29:5399-406
Nigam, Pragati; Velu, Vijayakumar; Kannanganat, Sunil et al. (2010) Expansion of FOXP3+ CD8 T cells with suppressive potential in colorectal mucosa following a pathogenic simian immunodeficiency virus infection correlates with diminished antiviral T cell response and viral control. J Immunol 184:1690-701
Titanji, Kehmia; Velu, Vijayakumar; Chennareddi, Lakshmi et al. (2010) Acute depletion of activated memory B cells involves the PD-1 pathway in rapidly progressing SIV-infected macaques. J Clin Invest 120:3878-90
Ganguly, Sumita; Liu, Jinyan; Pillai, Vinod B et al. (2010) Adjuvantive effects of anti-4-1BB agonist Ab and 4-1BBL DNA for a HIV-1 Gag DNA vaccine: different effects on cellular and humoral immunity. Vaccine 28:1300-9
Kannanganat, Sunil; Nigam, Pragati; Velu, Vijayakumar et al. (2010) Preexisting vaccinia virus immunity decreases SIV-specific cellular immunity but does not diminish humoral immunity and efficacy of a DNA/MVA vaccine. J Immunol 185:7262-73
Velu, Vijayakumar; Titanji, Kehmia; Zhu, Baogong et al. (2009) Enhancing SIV-specific immunity in vivo by PD-1 blockade. Nature 458:206-10

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