Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI060021-16
Application #
6843735
Study Section
Experimental Virology Study Section (EVR)
Program Officer
Park, Eun-Chung
Project Start
1985-07-01
Project End
2008-01-31
Budget Start
2005-02-01
Budget End
2006-01-31
Support Year
16
Fiscal Year
2005
Total Cost
$272,736
Indirect Cost
Name
University of Pennsylvania
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Zalinger, Zachary B; Elliott, Ruth; Weiss, Susan R (2017) Role of the inflammasome-related cytokines Il-1 and Il-18 during infection with murine coronavirus. J Neurovirol 23:845-854
Zalinger, Zachary B; Elliott, Ruth; Rose, Kristine M et al. (2015) MDA5 Is Critical to Host Defense during Infection with Murine Coronavirus. J Virol 89:12330-40
Fehr, Anthony R; Athmer, Jeremiah; Channappanavar, Rudragouda et al. (2015) The nsp3 macrodomain promotes virulence in mice with coronavirus-induced encephalitis. J Virol 89:1523-36
Phillips, Judith M; Kuo, I-Ting; Richardson, Chelsea et al. (2012) A novel full-length isoform of murine pregnancy-specific glycoprotein 16 (psg16) is expressed in the brain but does not mediate murine coronavirus (MHV) entry. J Neurovirol 18:138-43
Weiss, Susan R; Leibowitz, Julian L (2011) Coronavirus pathogenesis. Adv Virus Res 81:85-164
Phillips, Judith M; Weiss, Susan R (2011) Pathogenesis of neurotropic murine coronavirus is multifactorial. Trends Pharmacol Sci 32:2-7
Cowley, Timothy J; Long, Simon Y; Weiss, Susan R (2010) The murine coronavirus nucleocapsid gene is a determinant of virulence. J Virol 84:1752-63
Bender, Susan J; Weiss, Susan R (2010) Pathogenesis of murine coronavirus in the central nervous system. J Neuroimmune Pharmacol 5:336-54
Cowley, Timothy J; Weiss, Susan R (2010) Murine coronavirus neuropathogenesis: determinants of virulence. J Neurovirol 16:427-34
Bender, Susan J; Phillips, Judith M; Scott, Erin P et al. (2010) Murine coronavirus receptors are differentially expressed in the central nervous system and play virus strain-dependent roles in neuronal spread. J Virol 84:11030-44

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