West Nile virus (WNV) is an emerging infectious disease of public health importance. In humans, WNV can cause a life threatening illness and damage to the central nervous system (CNS). We have linked WNV infection outcome with the regulation of host cell pathogen recognition receptor (PRR) signaling programs of innate immunity that trigger interferon alpha/beta expression and that activate interferon regulatory factors (IRFs) to induce antiviral response genes that control infection. We now propose to determine the specific PRRs, IRFs, and their intracellular signaling pathways that control cell-specific imimune defenses and the outcome of WNV infection. Our studies will 1) Determine the effect of specific PRR and IRF genes on cell tropism of WNV infection, and 2) Define the PRRs and IRFs that serve to control CNS entry and pathogenesis of WNV infection. These studies will reveal the host innate immune signaling and response features that control WNV infection.
West Nile virus (WNV) is an emerging infectious disease of public health importance. In humans, WNV can cause a life threatening illness and damage to the central nervous system. We have linked WNV infection outcome with viral measures to trigger and control innate immunity. Our studies will define the innate immune functions that control WNV infection and spread.
| Luo, Huanle; Winkelmann, Evandro; Xie, Guorui et al. (2017) MAVS Is Essential for Primary CD4+ T Cell Immunity but Not for Recall T Cell Responses following an Attenuated West Nile Virus Infection. J Virol 91: |
| Quicke, Kendra M; Diamond, Michael S; Suthar, Mehul S (2017) Negative regulators of the RIG-I-like receptor signaling pathway. Eur J Immunol 47:615-628 |
| Zhao, Jincun; Vijay, Rahul; Zhao, Jingxian et al. (2016) MAVS Expressed by Hematopoietic Cells Is Critical for Control of West Nile Virus Infection and Pathogenesis. J Virol 90:7098-7108 |
| Nair, Sharmila; Diamond, Michael S (2015) Innate immune interactions within the central nervous system modulate pathogenesis of viral infections. Curr Opin Immunol 36:47-53 |
| Lazear, Helen M; Nice, Timothy J; Diamond, Michael S (2015) Interferon-?: Immune Functions at Barrier Surfaces and Beyond. Immunity 43:15-28 |
| Lazear, Helen M; Daniels, Brian P; Pinto, Amelia K et al. (2015) Interferon-? restricts West Nile virus neuroinvasion by tightening the blood-brain barrier. Sci Transl Med 7:284ra59 |
| Kell, Alison M; Gale Jr, Michael (2015) RIG-I in RNA virus recognition. Virology 479-480:110-21 |
| Chakrabarti, Arindam; Banerjee, Shuvojit; Franchi, Luigi et al. (2015) RNase L activates the NLRP3 inflammasome during viral infections. Cell Host Microbe 17:466-77 |
| Hussmann, Katherine L; Vandergaast, Rianna; Ochsner, Susan Park et al. (2014) In vitro and in vivo characterization of a West Nile virus MAD78 infectious clone. Arch Virol 159:3113-8 |
| Zhao, Jincun; Li, Kun; Wohlford-Lenane, Christine et al. (2014) Rapid generation of a mouse model for Middle East respiratory syndrome. Proc Natl Acad Sci U S A 111:4970-5 |
Showing the most recent 10 out of 28 publications
