Public Health Relevance

We have recently established that three dendritic cells subsets with separate lineages co-exist in the skin. In this grant application, we propose to dissect the origin of DC populations in the skin, identify the key molecules that control their development and examine the contribution of each DC lineage to the initiation of skin anti- microbial immune responses. We believe that these results will contribute to a better understanding of the immunological cues that govern skin immune responses. These results should also contribute to the design of novel vaccine strategies.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI080884-02
Application #
7898911
Study Section
Innate Immunity and Inflammation Study Section (III)
Program Officer
Nasseri, M Faraz
Project Start
2009-07-24
Project End
2012-06-30
Budget Start
2010-07-01
Budget End
2012-06-30
Support Year
2
Fiscal Year
2010
Total Cost
$423,750
Indirect Cost
Name
Icahn School of Medicine at Mount Sinai
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029
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