Tuberculosis (TB) continues to be a major health problem worldwide. Mycobacterium tuberculosis, the agent of human TB, uses proteins and other compounds called """"""""virulence factors"""""""" to subvert human host defenses and damage and invade human host cells during infection. The main goal of this project is to study a family of proteins necessary for M. tuberculosis success in host infection. Therefore, this study could bring insight in the knowledge of the mechanisms involved in the infective process of M. tuberculosis in humans. A better understanding of this process will contribute to the development of new strategies to control this disease including the design of an effective vaccine.
Tuberculosis (TB) continues to be a major health problem worldwide. Mycobacterium tuberculosis, the agent of human TB, uses proteins and other compounds called """"""""virulence factors"""""""" to subvert human host defenses and damage and invade human host cells during infection. The main goal of this project is to study a family of proteins necessary for M. tuberculosis success in host infection. Therefore, this study could bring insight in the knowledge of the mechanisms involved in the infective process of M. tuberculosis in humans. A better understanding of this process will contribute to the development of new strategies to control this disease including the design of an effective vaccine.
| Blanco, Federico Carlos; Bigi, Fabiana; Soria, Marcelo Abel (2014) Identification of potential biomarkers of disease progression in bovine tuberculosis. Vet Immunol Immunopathol 160:177-83 |
| Forrellad, Marina Andrea; McNeil, Michael; Santangelo, María de la Paz et al. (2014) Role of the Mce1 transporter in the lipid homeostasis of Mycobacterium tuberculosis. Tuberculosis (Edinb) 94:170-7 |
| Forrellad, Marina Andrea; Bianco, María Verónica; Blanco, Federico Carlos et al. (2013) Study of the in vivo role of Mce2R, the transcriptional regulator of mce2 operon in Mycobacterium tuberculosis. BMC Microbiol 13:200 |
| Forrellad, Marina A; Klepp, Laura I; Gioffre, Andrea et al. (2013) Virulence factors of the Mycobacterium tuberculosis complex. Virulence 4:3-66 |
| Blanco, Federico Carlos; Soria, Marcelo; Gravisaco, Maria Jose et al. (2012) Assessment of the immune responses induced in cattle after inoculation of a Mycobacterium bovis strain deleted in two mce2 genes. J Biomed Biotechnol 2012:258353 |
| Rizzi, Caroline; Bianco, Maria Veronica; Blanco, Federico Carlos et al. (2012) Vaccination with a BCG strain overexpressing Ag85B protects cattle against Mycobacterium bovis challenge. PLoS One 7:e51396 |
| Klepp, Laura I; Forrellad, Marina A; Osella, Ana V et al. (2012) Impact of the deletion of the six mce operons in Mycobacterium smegmatis. Microbes Infect 14:590-9 |
| Bianco, Maria V; Blanco, Federico C; Imperiale, Belen et al. (2011) Role of P27 -P55 operon from Mycobacterium tuberculosis in the resistance to toxic compounds. BMC Infect Dis 11:195 |
| Blanco, Federico Carlos; Bianco, Maria Veronica; Meikle, Virginia et al. (2011) Increased IL-17 expression is associated with pathology in a bovine model of tuberculosis. Tuberculosis (Edinb) 91:57-63 |
