Structure Based Characterization of gp120 Non-V3 Variable Loop Epitopes

Cardozo, Timothy J.; Kong, Xiangpeng

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Research Project (R01)
• Project #: 3R01AI084119-04S1
• Application #: 8733248
• Program Officer: Malaspina, Angela
• Project Start: 2014-01-29
• Project End: 2016-01-28
• Budget Start: 2014-01-29
• Budget End: 2016-01-28
• Support Year: 4
• Fiscal Year: 2014

Institution

• Name: New York University
• Department: Pharmacology
• Type: Schools of Medicine
• City: New York
• State: NY
• Country: United States
• Zip Code: 10016

Publications

Pan, Ruimin; Gorny, Miroslaw K; Zolla-Pazner, Susan et al. (2015) The V1V2 Region of HIV-1 gp120 Forms a Five-Stranded Beta Barrel. J Virol 89:8003-10

Shmelkov, Evgeny; Nadas, Arthur; Cardozo, Timothy (2014) Could vaccination with AIDSVAX immunogens have resulted in antibody-dependent enhancement of HIV infection in human subjects? Hum Vaccin Immunother 10:3013-6

Spurrier, Brett; Sampson, Jared; Gorny, Miroslaw K et al. (2014) Functional implications of the binding mode of a human conformation-dependent V2 monoclonal antibody against HIV. J Virol 88:4100-12

Shmelkov, Evgeny; Grigoryan, Arsen; Krachmarov, Chavdar et al. (2014) Sequence-conserved and antibody-accessible sites in the V1V2 domain of HIV-1 gp120 envelope protein. AIDS Res Hum Retroviruses 30:927-31

Cardozo, Timothy; Wang, Shixia; Jiang, Xunqing et al. (2014) Vaccine focusing to cross-subtype HIV-1 gp120 variable loop epitopes. Vaccine 32:4916-24

Zolla-Pazner, Susan; deCamp, Allan C; Cardozo, Timothy et al. (2013) Analysis of V2 antibody responses induced in vaccinees in the ALVAC/AIDSVAX HIV-1 vaccine efficacy trial. PLoS One 8:e53629

Karasavvas, Nicos; Billings, Erik; Rao, Mangala et al. (2012) The Thai Phase III HIV Type 1 Vaccine trial (RV144) regimen induces antibodies that target conserved regions within the V2 loop of gp120. AIDS Res Hum Retroviruses 28:1444-57

Gorny, Miroslaw K; Pan, Ruimin; Williams, Constance et al. (2012) Functional and immunochemical cross-reactivity of V2-specific monoclonal antibodies from HIV-1-infected individuals. Virology 427:198-207

Spurrier, Brett; Sampson, Jared M; Totrov, Maxim et al. (2011) Structural analysis of human and macaque mAbs 2909 and 2.5B: implications for the configuration of the quaternary neutralizing epitope of HIV-1 gp120. Structure 19:691-9

Shmelkov, Evgeny; Nadas, Arthur; Swetnam, James et al. (2011) Indirect detection of an epitope-specific response to HIV-1 gp120 immunization in human subjects. PLoS One 6:e27279