Duke University NIH R01 PI: Prudhomme-O'Meara Scope of work for Duke University Duke University will provide overall scientific leadership and coordination of the project. Duke University faculty member Dr. Wendy O'Meara will be the principal investigator for this project. She will oversee the entire project, including collaboratin with Moi University and government collaborators, coordination of study teams, data collection, data analysis and report writing. She will commit 4.8 calendar months in each year of the project. Other Duke University investigators will provide expertise in economics and biostatistics for development of the project tools, analysis and interpretation of results. Dr. Mohanan will be the primary supervisor for the doctoral candidate and will oversee development of his/her work within the project. Dr. Turner will supervise Alyssa Platt (staff biostatistician). A post-doctoral associate will be engaged to lead the economic analysis of the survey data and to provide oversight of the survey data collection, ensuring quality of the data and assisting with the analysis and interpretation. Duke-based study coordinator, Adriane Lesser, and the Duke financial administration team will provide oversight of the budget, procurement of supplies including rapid diagnostic tests, collaboration with Moi University financial office, and will be responsible for reporting activities. Ms. Lesser will also facilitate communication between the sites and will help integrate the Research Assistants into the project.
This project will tackle an important implementation research problem. We will evaluate a new approach to improve access to diagnosis for malaria amongst those patients who seek malaria treatment in the informal health sector. This will lead to improved targeting of subsidized antimalarial to those patients who need them and reduce overuse and over-treatment. The approach uses an innovative public-private partnership between community health workers and retail medicine shops. The project will be conducted in collaboration with Kenya's Division of Malaria Control and avenues to roll-out the intervention, if successful, will be actively explored.
|Boyce, Matthew R; Menya, Diana; Turner, Elizabeth L et al. (2018) Evaluation of malaria rapid diagnostic test (RDT) use by community health workers: a longitudinal study in western Kenya. Malar J 17:206|
|Nkumama, Irene N; O'Meara, Wendy P; Osier, Faith H A (2017) Changes in Malaria Epidemiology in Africa and New Challenges for Elimination. Trends Parasitol 33:128-140|
|Turner, Elizabeth L; Prague, Melanie; Gallis, John A et al. (2017) Review of Recent Methodological Developments in Group-Randomized Trials: Part 2-Analysis. Am J Public Health 107:1078-1086|
|Saran, Indrani; Maffioli, Elisa M; Menya, Diana et al. (2017) Household beliefs about malaria testing and treatment in Western Kenya: the role of health worker adherence to malaria test results. Malar J 16:349|
|Laktabai, Jeremiah; Lesser, Adriane; Platt, Alyssa et al. (2017) Innovative public-private partnership to target subsidised antimalarials: a study protocol for a cluster randomised controlled trial to evaluate a community intervention in Western Kenya. BMJ Open 7:e013972|
|Turner, Elizabeth L; Li, Fan; Gallis, John A et al. (2017) Review of Recent Methodological Developments in Group-Randomized Trials: Part 1-Design. Am J Public Health 107:907-915|
|Prudhomme O'Meara, Wendy; Mohanan, Manoj; Laktabai, Jeremiah et al. (2016) Assessing the independent and combined effects of subsidies for antimalarials and rapid diagnostic testing on fever management decisions in the retail sector: results from a factorial randomised trial in western Kenya. BMJ Glob Health 1:e000101|