Pneumococcal vaccination is underused in underserved minorities, who are at greater pneumococcal disease risk. Two vaccines are available, the older pneumococcal polysaccharide vaccine (PPSV) and the 13-valent pneumococcal conjugate vaccine (PCV13). However, the optimally protective vaccination regimen is unclear, due to changing epidemiology and uncertain vaccine effectiveness; both should become clearer soon. Current CDC vaccination recommendations are complex and may not optimally protect the underserved, due multiple barriers to effective implementation. Vaccine uptake could improve with either better implementation of cur- rent recommendations or broader CDC recommendations that are easier to implement, which could have pro-portionately greater effects on the underserved. Clinical trials comparing these strategies are unlikely and, due to the moving target of vaccination-related epidemiologic changes and US Affordable Care Act (ACA) effects on vaccination rates, could be unhelpful. To investigate these issues, a systematic synthesis of available data and evidence-based projections with rigor- ous modeling of uncertainty is planned to assist policymaking and inform research resource allocation. Potential changes to decrease the complexity of pneumococcal vaccination recommendations (using PPSV and/or PCV13) will be modeled and compared to current recommendations implemented under programs to improve vaccination rates.
Specific aims are to: 1) compare the public health impact on underserved minority populations of potential CDC adult pneumococcal vaccination recommendations, specifically addressing age-based vs. the more complex comorbidity-based use of vaccine; and 2) determine the public health impact and cost- effectiveness of implementation programs to improve vaccination rates in underserved minorities and persons <65 with high risk conditions, compared to potential CDC vaccination recommendations from Aim 1. Vaccination strategies will be compared via Markov model-based cost-effectiveness analysis, with probabilistic sensitivity analysis and value of information analysis to determine favored strategies and identify the most valuable areas for future research. Analyses will also innovatively use the CDC-recommended RE-AIM framework to evaluate implementation program options and explore interactions between ACA effects, potential CDC recommendations, and race-specific pneumococcal disease characteristics. Since CDC vaccination recommendation evaluations increasingly consider economic analyses, analysis results can be used, as they have previously, to assist vaccination recommendation decisions and potentially change vaccination policy to better protect the underserved.

Public Health Relevance

Pneumococcal disease continues to be an important public health problem, particularly in underserved minorities. This project will evaluate vaccination strategies to improve vaccination protection in this group

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI116575-02
Application #
9172236
Study Section
Health Services Organization and Delivery Study Section (HSOD)
Program Officer
Lu, Kristina
Project Start
2015-11-01
Project End
2019-10-31
Budget Start
2016-11-01
Budget End
2017-10-31
Support Year
2
Fiscal Year
2017
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Wateska, Angela R; Nowalk, Mary Patricia; Zimmerman, Richard K et al. (2018) Cost-effectiveness of increasing vaccination in high-risk adults aged 18-64 Years: a model-based decision analysis. BMC Infect Dis 18:52
Smith, Kenneth J; Zimmerman, Richard K; Nowalk, Mary Patricia et al. (2017) Cost-Effectiveness of the 4 Pillars Practice Transformation Program to Improve Vaccination of Adults Aged 65 and Older. J Am Geriatr Soc 65:763-768