Malaria is highly endemic in the Democratic Republic of the Congo (DRC). Malaria control efforts in the DRC have ramped up in recent years, but resources and local knowledge are still limited. The overall research goal of this project is to provide the evidence base to assist in the development of sustainable control and elimination strategies for the DRC through the integrated understanding of the local malaria epidemiology, vector biology and parasite genetics. Through a longitudinal cohort study of 1600 individuals in 7 sites with differing transmission intensities, we will: 1) identify risk factors for patent, subpatent and clinical malaria in a longitudinal study; 2) Assess changes in entomological parameters longitudinally including species, behavior and insecticide-resistance; 3) Measure genetic changes in the parasite longitudinally especially in drug-resistance SNPs and in deletions of the pfhrp2 gene; and 4) create multilevel statistical models to determine the relationships between these cofactors and events. The results of this study will have a direct impact on malaria control efforts in the DRC and other countries in sub-Saharan Africa.

Public Health Relevance

10% of the world?s malaria is believed to be in the Democratic Republic of the Congo. Here we propose a comprehensive longitudinal study of human and mosquito factors that affect malaria transmission.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI129812-03
Application #
9685111
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Rao, Malla R
Project Start
2017-05-01
Project End
2022-04-30
Budget Start
2019-05-01
Budget End
2020-04-30
Support Year
3
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Kinshasa School of Public Health
Department
Type
DUNS #
565493868
City
Kinshasa
State
Country
Congo Dem Rep
Zip Code
11850