Using epididymal fat tissue and isolated cells, the studies are directed at uncovering the relationships of the various effects of growth to each other and to hormone binding. The events involved in the initial insulin-like response and the cellular processes that counter these effects will be explored in detail in an effort to determine whether the spectrum of growth hormone effects arise from a single unique interaction between the tissue and the hormone or from a series of independent actions. Ultimately, it is intended to relate these early rapid events to the overall process of growth promotion and regulation.
| Szecowka, J; Tai, L R; Goodman, H M (1990) Effects of tunicamycin on growth hormone binding in rat adipocytes. Endocrinology 126:1834-41 |
| Frick, G P; Leonard, J L; Goodman, H M (1990) Effect of hypophysectomy on growth hormone receptor gene expression in rat tissues. Endocrinology 126:3076-82 |
| Gorin, E; Honeyman, T W; Tai, L R et al. (1988) Adenosine 3',5'-monophosphate-dependent loss of growth hormone binding in rat adipocytes. Endocrinology 123:328-34 |
| Coiro, V; Goodman, H M (1987) Pituitary secretions related to adrenocorticotropic hormone induce sensitivity of adipose tissue to the insulin-like actions of growth hormone. Neuroendocrinology 45:165-71 |
| Grichting, G; Goodman, H M (1986) Growth hormone maintains its own receptors in rat adipocytes. Endocrinology 119:847-54 |
| Gorin, E; Goodman, H M (1985) Turnover of growth hormone receptors in rat adipocytes. Endocrinology 116:1796-805 |
