Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases (NIADDK)
Type
Research Project (R01)
Project #
3R01AM025116-08S1
Application #
3151467
Study Section
Metabolism Study Section (MET)
Project Start
1978-09-15
Project End
1987-02-28
Budget Start
1986-09-01
Budget End
1987-02-28
Support Year
8
Fiscal Year
1986
Total Cost
Indirect Cost
Name
University of Rochester
Department
Type
Schools of Medicine
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627
Arner, P; Einarsson, K; Ewerth, S et al. (1987) Altered action of glucagon on human liver in type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 30:323-6
Arsenis, G; Livingston, J N (1986) Isoproterenol reduces insulin stimulation of hexose uptake by rat adipocytes via a postinsulin binding alteration. Endocrinology 119:50-7
Arner, P; Einarsson, K; Ewerth, S et al. (1986) Studies of the human liver insulin receptor in noninsulin-dependent diabetes mellitus. J Clin Invest 77:1716-8
Oefelein, M G; Arsenis, G; Livingston, J N (1986) Insulin-stimulated fluid-phase pinocytosis and internalization of the insulin receptor: differences between the U-937 monocyte and rat adipocyte. Metabolism 35:818-23
Lerea, K M; Livingston, J N (1986) A thiol-sensitive degradative process of liver uncouples autophosphorylation of the insulin receptor from insulin binding. Biochem J 236:535-42
Arsenis, G; Livingston, J N (1986) Alterations in the tyrosine kinase activity of the insulin receptor produced by in vitro hyperinsulinemia. J Biol Chem 261:147-53
Livingston, J N; Einarsson, K; Backman, L et al. (1985) Glucagon receptor of human liver. Studies of its molecular weight and binding properties, and its ability to activate hepatic adenylyl cyclase of non-obese and obese subjects. J Clin Invest 75:397-403
Livingston, J N; Saran, B R; Rose, C D et al. (1985) Rapid effects of insulin on the cycling of the insulin receptor in a human monocyte cell line (U-937). Diabetes 34:403-8
Amatruda, J M; Livingston, J N; Lockwood, D H (1985) Cellular mechanisms in selected states of insulin resistance: human obesity, glucocorticoid excess, and chronic renal failure. Diabetes Metab Rev 1:293-317
Arsenis, G; Hayes, G R; Livingston, J N (1985) Insulin receptor cycling and insulin action in the rat adipocyte. J Biol Chem 260:2202-7