The objective of this study is the development and testing of a quantitative optical model of striated muscle for the purpose of distinguishing between different mechano-chemical transduction mechanisms. The birefringence properties of striated muscle will be determined under a variety of experimental conditions in which the constituent components of muscle are either organized, constrained or removed in a well defined manner. The optical model will then be used to interpret the birefringence properties of muscle in terms of parameters which are important for a quantitative description of the mechano-chemical transduction process. The extension of these studies to smooth muscle is also contemplated. A full understanding of how chemical energy is converted into work during muscle contraction is important in many areas of physiology and medicine.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR012803-30
Application #
3154763
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1976-12-01
Project End
1992-08-31
Budget Start
1989-09-01
Budget End
1990-08-31
Support Year
30
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Type
Schools of Arts and Sciences
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218