Much controversy exists over the significance of the knee laxity exam. This has resulted, in part, from a lack of knowledge as to the restraining functions of the various ligaments and capsular structures. During the first grant period we measured the ligament restraints to the so-called """"""""straight instabilites."""""""" These are anterior-posterior drawer and straight medial-lateral opening. In the proposed renewal period we will study the restraining action of the ligaments to the rotatory instabilities. These instabilities involve combined rotational and translational knee motion. The rotatory motion is that associated with axial tibial rotation. The translations are anterior-posterior drawer and medial-lateral shifting of the tibia. We propose to address the problem of defining the significance of rotatory laxities, with regard to injury, by applying three distinct methodologies. These are described below in separate projects. They include: 1) Measuring the three-dimensional restraining forces of the ligaments to well defined and reproducible rotations of the tibia, 2) measuring the three-dimensional motions which occur during the various clinical exams for rotatory instability along with the changes in motion associated with specific ligament injuries, and 3) synthesizing these results on ligament function into a mathematical model capable of testing our understanding of both the effects of the various individual factors (i.e., ligaments, joint geometry, compressive forces, etc.) and their complex interactions.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR021172-09
Application #
3155148
Study Section
Orthopedics and Musculoskeletal Study Section (ORTH)
Project Start
1978-01-01
Project End
1988-12-31
Budget Start
1986-01-01
Budget End
1986-12-31
Support Year
9
Fiscal Year
1986
Total Cost
Indirect Cost
Name
University of Cincinnati
Department
Type
Schools of Medicine
DUNS #
City
Cincinnati
State
OH
Country
United States
Zip Code
45221
Cummings, J F; Grood, E S; Butler, D L et al. (2002) Subject variation in caprine anterior cruciate ligament reconstruction. J Orthop Res 20:1009-15
Cummings, J F; Grood, E S; Levy, M S et al. (2002) The effects of graft width and graft laxity on the outcome of caprine anterior cruciate ligament reconstruction. J Orthop Res 20:338-45
Cummings, J F; Grood, E S (2002) The progression of anterior translation after anterior cruciate ligament reconstruction in a caprine model. J Orthop Res 20:1003-8
Neidlinger-Wilke, C; Grood, E S; Wang JH-C et al. (2001) Cell alignment is induced by cyclic changes in cell length: studies of cells grown in cyclically stretched substrates. J Orthop Res 19:286-93
Galloway, M T; Grood, E S; Mehalik, J N et al. (1996) Posterior cruciate ligament reconstruction. An in vitro study of femoral and tibial graft placement. Am J Sports Med 24:437-45
Nabeshima, Y; Grood, E S; Sakurai, A et al. (1996) Uniaxial tension inhibits tendon collagen degradation by collagenase in vitro. J Orthop Res 14:123-30
Bush-Joseph, C A; Cummings, J F; Buseck, M et al. (1996) Effect of tibial attachment location on the healing of the anterior cruciate ligament freeze model. J Orthop Res 14:534-41
Haimes, J L; Wroble, R R; Grood, E S et al. (1994) Role of the medial structures in the intact and anterior cruciate ligament-deficient knee. Limits of motion in the human knee. Am J Sports Med 22:402-9
Noyes, F R; Stowers, S F; Grood, E S et al. (1993) Posterior subluxations of the medial and lateral tibiofemoral compartments. An in vitro ligament sectioning study in cadaveric knees. Am J Sports Med 21:407-14
Wroble, R R; Grood, E S; Cummings, J S et al. (1993) The role of the lateral extraarticular restraints in the anterior cruciate ligament-deficient knee. Am J Sports Med 21:257-62;discussion 263

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