Abstract

The objectives of this proposal are to optimize the predictability of neocartilage growth from perichondrium by the further investigation of fixation techniques as well as exploration of the role of mechanical factors on neocartilage formation. A spectrum of mechanical factors from complete immobilization to intermittent continuous passive motion will be studied (ICPM). Further characterization of the arthroplasty surface will be made using biochemical, biomechanical and morphological techniques. Normal articular cartilage will serve as a control. The significant rate of failure of total joint replacement surgery has stimulated a renewed interest in biological arthroplasty, particularly for young of middle aged patients. The recent observation that rib perichondrium transplanted to a joint will proliferate to form hyaline cartilage offers an exciting avenue for a new research direction in this field.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR028467-06
Application #
3155669
Study Section
Orthopedics and Musculoskeletal Study Section (ORTH)
Project Start
1981-04-01
Project End
1987-03-31
Budget Start
1986-04-01
Budget End
1987-03-31
Support Year
6
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
University of California San Diego
Department
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Ball, Scott T; Goomer, Randal S; Ostrander, Roger V et al. (2004) Preincubation of tissue engineered constructs enhances donor cell retention. Clin Orthop Relat Res :276-85
Giurea, Alexander; Klein, Travis J; Chen, Albert C et al. (2003) Adhesion of perichondrial cells to a polylactic acid scaffold. J Orthop Res 21:584-9
Goomer, R S; Deftos, L J; Terkeltaub, R et al. (2001) High-efficiency non-viral transfection of primary chondrocytes and perichondrial cells for ex-vivo gene therapy to repair articular cartilage defects. Osteoarthritis Cartilage 9:248-56
Coutts, R D; Healey, R M; Ostrander, R et al. (2001) Matrices for cartilage repair. Clin Orthop Relat Res :S271-9
Ostrander, R V; Goomer, R S; Tontz, W L et al. (2001) Donor cell fate in tissue engineering for articular cartilage repair. Clin Orthop Relat Res :228-37
Lane, J G; Tontz Jr, W L; Ball, S T et al. (2001) A morphologic, biochemical, and biomechanical assessment of short-term effects of osteochondral autograft plug transfer in an animal model. Arthroscopy 17:856-63
Takahashi, K; Hashimoto, S; Kubo, T et al. (2001) Hyaluronan suppressed nitric oxide production in the meniscus and synovium of rabbit osteoarthritis model. J Orthop Res 19:500-3
Takahashi, K; Hashimoto, S; Kubo, T et al. (2000) Effect of hyaluronan on chondrocyte apoptosis and nitric oxide production in experimentally induced osteoarthritis. J Rheumatol 27:1713-20
Dounchis, J S; Bae, W C; Chen, A C et al. (2000) Cartilage repair with autogenic perichondrium cell and polylactic acid grafts. Clin Orthop Relat Res :248-64
Goomer, R S; Maris, T M; Gelberman, R et al. (2000) Nonviral in vivo gene therapy for tissue engineering of articular cartilage and tendon repair. Clin Orthop Relat Res :S189-200

Showing the most recent 10 out of 28 publications