Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR030134-16
Application #
2078680
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1993-12-20
Project End
1996-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
16
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Mehraban, F; Tindal, M H; Proffitt, M M et al. (1997) Temporal pattern of cysteine endopeptidase (cathepsin B) expression in cartilage and synovium from rabbit knees with experimental osteoarthritis: gene expression in chondrocytes in response to interleukin-1 and matrix depletion. Ann Rheum Dis 56:108-15
Denko, C W; Boja, B; Moskowitz, R W (1996) Growth factors, insulin-like growth factor-1 and growth hormone, in synovial fluid and serum of patients with rheumatic disorders. Osteoarthritis Cartilage 4:245-9
Pokharna, H K; Monnier, V; Boja, B et al. (1995) Lysyl oxidase and Maillard reaction-mediated crosslinks in aging and osteoarthritic rabbit cartilage. J Orthop Res 13:13-21
Denko, C W; Boja, B; Moskowitz, R W (1994) Growth promoting peptides in osteoarthritis and diffuse idiopathic skeletal hyperostosis--insulin, insulin-like growth factor-I, growth hormone. J Rheumatol 21:1725-30
Mehraban, F; Kuo, S Y; Riera, H et al. (1994) Prostromelysin and procollagenase genes are differentially up-regulated in chondrocytes from the knees of rabbits with experimental osteoarthritis. Arthritis Rheum 37:1189-97
Moskowitz, R W; Reese, J H; Young, R G et al. (1991) The effects of Rumalon, a glycosaminoglycan peptide complex, in a partial meniscectomy model of osteoarthritis in rabbits. J Rheumatol 18:205-9
Moskowitz, R W; Boja, B; Denko, C W (1991) The role of growth factors in degenerative joint disorders. J Rheumatol Suppl 27:147-8
Denko, C W; Boja, B; Moskowitz, R W (1990) Growth promoting peptides in osteoarthritis: insulin, insulin-like growth factor-1, growth hormone. J Rheumatol 17:1217-21
Mehraban, F; Moskowitz, R W (1989) Serum keratan sulfate levels in rabbits with experimentally induced osteoarthritis. Arthritis Rheum 32:1293-9