Abstract

To determine the molecular role of MHC class II alleles in susceptibility to EBA, the HLA-DRB, DQA genes and products will be studied by RFLP analysis, gene amplification and sequencing and by serologic subtyping. The data will be analyzed and compared with matched healthy controls to determine whether any HLA nucleotide sequences and deduced amino acid sequences of polymorphic regions are associated are common to the DR2, DQ haplotypes response to the specific epitope on the noncollagenous part of collagen type VII.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
2R01AR030475-07
Application #
3155813
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1982-09-30
Project End
1994-03-31
Budget Start
1989-04-15
Budget End
1990-03-31
Support Year
7
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599

  Publications

Jones, D A; Hunt 3rd, S W; Prisayanh, P S et al. (1995) Immunodominant autoepitopes of type VII collagen are short, paired peptide sequences within the fibronectin type III homology region of the noncollagenous (NC1) domain. J Invest Dermatol 104:231-5
Shimizu, K; Hashimoto, T; Fukuda, T et al. (1995) A Japanese case of the fibrillar type of dermatitis herpetiformis. Dermatology 191:88-92
Gammon, W R; Briggaman, R A (1993) Epidermolysis bullosa acquisita and bullous systemic lupus erythematosus. Diseases of autoimmunity to type VII collagen. Dermatol Clin 11:535-47
Thuong-Nguyen, V; Kadunce, D P; Hendrix, J D et al. (1993) Inhibition of neutrophil adherence to antibody by dapsone: a possible therapeutic mechanism of dapsone in the treatment of IgA dermatoses. J Invest Dermatol 100:349-55
Gammon, W R; Briggaman, R A (1993) Bullous SLE: a phenotypically distinctive but immunologically heterogeneous bullous disorder. J Invest Dermatol 100:28S-34S
Jenison, M; Fine, J D; Gammon, W R et al. (1993) Normal molecular weight of type VII collagen produced by recessive dystrophic epidermolysis bullosa keratinocytes. J Invest Dermatol 100:93-6
Dmochowski, M; Hashimoto, T; Bhogal, B S et al. (1993) Immunoblotting studies of linear IgA disease. J Dermatol Sci 6:194-200
Gammon, W R; Murrell, D F; Jenison, M W et al. (1993) Autoantibodies to type VII collagen recognize epitopes in a fibronectin-like region of the noncollagenous (NC1) domain. J Invest Dermatol 100:618-22
Domloge-Hultsch, N; Benson, P; Gammon, W R et al. (1992) A bullous skin disease patient with autoantibodies against separate epitopes in 1 mol/L sodium chloride split skin. Arch Dermatol 128:1096-101
Gammon, W R; Fine, J D; Forbes, M et al. (1992) Immunofluorescence on split skin for the detection and differentiation of basement membrane zone autoantibodies. J Am Acad Dermatol 27:79-87

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