Peptide Growth Factors and Skeletal Development

Trippel, Stephen B.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
• Type: Research Project (R01)
• Project #: 5R01AR031068-13
• Application #: 2078757
• Study Section: Orthopedics and Musculoskeletal Study Section (ORTH)
• Project Start: 1981-09-01
• Project End: 1998-08-31
• Budget Start: 1996-09-01
• Budget End: 1997-08-31
• Support Year: 13
• Fiscal Year: 1996

Institution

• Name: Massachusetts General Hospital
• City: Boston
• State: MA
• Country: United States
• Zip Code: 02199

Publications

Takahashi, Toshiaki; Morris, Elisabeth A; Trippel, Stephen B (2007) Bone morphogenetic protein-2 and -9 regulate the interaction of insulin-like growth factor-I with growth plate chondrocytes. Int J Mol Med 20:53-7

Madry, H; Kaul, G; Cucchiarini, M et al. (2005) Enhanced repair of articular cartilage defects in vivo by transplanted chondrocytes overexpressing insulin-like growth factor I (IGF-I). Gene Ther 12:1171-9

Madry, Henning; Emkey, Greg; Zurakowski, David et al. (2004) Overexpression of human fibroblast growth factor 2 stimulates cell proliferation in an ex vivo model of articular chondrocyte transplantation. J Gene Med 6:238-45

Madry, Henning; Cucchiarini, Magali; Stein, Ute et al. (2003) Sustained transgene expression in cartilage defects in vivo after transplantation of articular chondrocytes modified by lipid-mediated gene transfer in a gel suspension delivery system. J Gene Med 5:502-9

Madry, Henning; Cucchiarini, Magali; Terwilliger, Ernest F et al. (2003) Recombinant adeno-associated virus vectors efficiently and persistently transduce chondrocytes in normal and osteoarthritic human articular cartilage. Hum Gene Ther 14:393-402

Madry, Henning; Padera, Robert; Seidel, Joachim et al. (2002) Gene transfer of a human insulin-like growth factor I cDNA enhances tissue engineering of cartilage. Hum Gene Ther 13:1621-30

Bonassar, L J; Grodzinsky, A J; Frank, E H et al. (2001) The effect of dynamic compression on the response of articular cartilage to insulin-like growth factor-I. J Orthop Res 19:11-7

Madry, H; Zurakowski, D; Trippel, S B (2001) Overexpression of human insulin-like growth factor-I promotes new tissue formation in an ex vivo model of articular chondrocyte transplantation. Gene Ther 8:1443-9

Madry, H; Trippel, S B (2000) Efficient lipid-mediated gene transfer to articular chondrocytes. Gene Ther 7:286-91

Bonassar, L J; Grodzinsky, A J; Srinivasan, A et al. (2000) Mechanical and physicochemical regulation of the action of insulin-like growth factor-I on articular cartilage. Arch Biochem Biophys 379:57-63