Abstract

This research program is designed to investigate the functional relationship between the loading characteristics of total joint components and remodeling of the supporting trabecular bone. In order to investigate these relationships, a hydraulically activated implant has been developed which when interfaced with a plane of trabecular bone in the distal femoral metaphysis of large dogs enables experimental control of the loading magnitude, frequency, number of cycles, and loading rate. This implant has already been demonstrated to elicit significant trabecular bone remodeling at the loading platen bone interface. These remodeling responses are characterized utilizing three-dimensional microcomputed tomography, histologic analysis, and mechanical testing. The specific objective of this proposal is to evaluate the relationship between implant design characteristics and trabecular bone ingrowth and remodeling. The quality of bone ingrowth as well as the morphology and architecture of the adjacent bone will be documented as a function of controlled implant mediated load.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR031793-07
Application #
3156095
Study Section
Orthopedics and Musculoskeletal Study Section (ORTH)
Project Start
1983-12-01
Project End
1994-04-30
Budget Start
1992-05-01
Budget End
1993-04-30
Support Year
7
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Moalli, M R; Caldwell, N J; Patil, P V et al. (2000) An in vivo model for investigations of mechanical signal transduction in trabecular bone. J Bone Miner Res 15:1346-53
Guldberg, R E; Hollister, S J; Charras, G T (1998) The accuracy of digital image-based finite element models. J Biomech Eng 120:289-95
Guldberg, R E; Caldwell, N J; Guo, X E et al. (1997) Mechanical stimulation of tissue repair in the hydraulic bone chamber. J Bone Miner Res 12:1295-302
Guldberg, R E; Richards, M; Caldwell, N J et al. (1997) Trabecular bone adaptation to variations in porous-coated implant topology. J Biomech 30:147-53
Hollister, S J; Guldberg, R E; Kuelske, C L et al. (1996) Relative effects of wound healing and mechanical stimulus on early bone response to porous-coated implants. J Orthop Res 14:654-62
Choi, K; Goldstein, S A (1992) A comparison of the fatigue behavior of human trabecular and cortical bone tissue. J Biomech 25:1371-81
Goldstein, S A; Matthews, L S; Kuhn, J L et al. (1991) Trabecular bone remodeling: an experimental model. J Biomech 24 Suppl 1:135-50
Hollister, S J; Fyhrie, D P; Jepsen, K J et al. (1991) Application of homogenization theory to the study of trabecular bone mechanics. J Biomech 24:825-39
Kuhn, J L; Goulet, R W; Pappas, M et al. (1990) Morphometric and anisotropic symmetries of the canine distal femur. J Orthop Res 8:776-80
Kuhn, J L; Goldstein, S A; Feldkamp, L A et al. (1990) Evaluation of a microcomputed tomography system to study trabecular bone structure. J Orthop Res 8:833-42

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