Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
7R01AR035297-03
Application #
3157146
Study Section
Pathobiochemistry Study Section (PBC)
Project Start
1987-01-01
Project End
1989-08-31
Budget Start
1987-01-01
Budget End
1987-08-31
Support Year
3
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Thomas Jefferson University
Department
Type
Schools of Medicine
DUNS #
061197161
City
Philadelphia
State
PA
Country
United States
Zip Code
19107
Muona, P; Sollberg, S; Peltonen, J et al. (1992) Glucose transporters of rat peripheral nerve. Differential expression of GLUT1 gene by Schwann cells and perineural cells in vivo and in vitro. Diabetes 41:1587-96
Mauviel, A; Kahari, V M; Evans, C H et al. (1992) Transcriptional activation of fibroblast collagenase gene expression by a novel lymphokine, leukoregulin. J Biol Chem 267:5644-8
Peltonen, J; Jaakkola, S; Uitto, J (1991) In situ hybridization and immunodetection techniques for simultaneous localization of messenger RNAs and protein epitopes in tissue sections and cultured cells. Methods Enzymol 203:476-84
Kahari, V M; Larjava, H; Uitto, J (1991) Differential regulation of extracellular matrix proteoglycan (PG) gene expression. Transforming growth factor-beta 1 up-regulates biglycan (PGI), and versican (large fibroblast PG) but down-regulates decorin (PGII) mRNA levels in human fibroblasts in cult J Biol Chem 266:10608-15
Peltonen, J; Hsiao, L L; Jaakkola, S et al. (1991) Activation of collagen gene expression in keloids: co-localization of type I and VI collagen and transforming growth factor-beta 1 mRNA. J Invest Dermatol 97:240-8
Sollberg, S; Muona, P; Lebwohl, M et al. (1991) Presence of type I and VI collagen mRNAs in endothelial cells in cutaneous neurofibromas. Lab Invest 65:237-42
Muona, P; Peltonen, J; Jaakkola, S et al. (1991) Increased matrix gene expression by glucose in rat neural connective tissue cells in culture. Diabetes 40:605-11
Peltonen, J; Varga, J; Sollberg, S et al. (1991) Elevated expression of the genes for transforming growth factor-beta 1 and type VI collagen in diffuse fasciitis associated with the eosinophilia-myalgia syndrome. J Invest Dermatol 96:20-5
Hsiao, L L; Peltonen, J; Jaakkola, S et al. (1991) Plasticity of integrin expression by nerve-derived connective tissue cells. Human Schwann cells, perineurial cells, and fibroblasts express markedly different patterns of beta 1 integrins during nerve development, neoplasia, and in vitro. J Clin Invest 87:811-20
Uitto, J (1991) Molecular pathology of collagen in cutaneous diseases. Adv Dermatol 6:265-86;discussion 287

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