The goal of this project is to further understand the autoimmune disease, systemic lupus erythematosis. Cloned V genes from autoantibodies will be used to investigate the origin and nature of autoantibodies and the mechanism of autoantibody production as compared to """"""""normal"""""""" antibodies. The hypothesis that autoantibodies are encoded by a biased part of the normal repertoire will be tested as will the role of somatic mutation and idiotype networks. The information gained from these experiments may provide useful diagnostic and therapeutic reagents for lupus.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR038821-04
Application #
3158814
Study Section
Allergy and Immunology Study Section (ALY)
Project Start
1986-09-01
Project End
1992-08-31
Budget Start
1989-09-01
Budget End
1990-08-31
Support Year
4
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Tufts University
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02111