Current clinical trends in total joint replacement (TJR) include implantation in younger patients and the use of non-cemented, porous coated metallic components which release greater amounts of corrosion products. In vitro and in vivo (animal and human) studies suggest a wide range of possible local and systemic biological sequelae to metallic release by TJRs. The proposed studies will address an important precursor to understanding the clinical significance of such effects: characterization of the release transport an storage of metallic moieties in patients with total hip replacements (THRs). This proposal involves three studies that will focus on distinct patient populations. The first study is a prospective, longitudinal study of metal ion release in patients undergoing primary THR with either a cementless titanium-base alloy prosthesis, a cementless cobalt-base alloy prosthesis or a cemented cobalt-base alloy prosthesis. The second study will examine metal ion release and local metal ion accumulation in patients undergoing revision THR for aseptic loosening of both cemented and cementless titanium-base alloy and cobalt-base alloy prosthesis. The third study will examine total body metal inventories in deceased individuals with cemented and cementless titanium-base alloy or cobalt-base alloy THRs. The primary analytical toll is Zeeman atomic absorption spectrophotometry (ZAAS). The results of theses studies will be critical in evaluating prospective risk to patients of the use of emerging total joint replacement technologies.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR039310-04
Application #
3159342
Study Section
Orthopedics and Musculoskeletal Study Section (ORTH)
Project Start
1989-05-01
Project End
1994-04-30
Budget Start
1992-05-01
Budget End
1994-04-30
Support Year
4
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Rush University Medical Center
Department
Type
DUNS #
City
Chicago
State
IL
Country
United States
Zip Code
60612
Lachiewicz, Paul F; Watters, Tyler Steven; Jacobs, Joshua J (2016) Metal Hypersensitivity and Total Knee Arthroplasty. J Am Acad Orthop Surg 24:106-12
Hallab, Nadim J; Caicedo, Marco; McAllister, Kyron et al. (2013) Asymptomatic prospective and retrospective cohorts with metal-on-metal hip arthroplasty indicate acquired lymphocyte reactivity varies with metal ion levels on a group basis. J Orthop Res 31:173-82
Hsu, Andrew R; Levine, Brett R; Skipor, Anastasia K et al. (2013) Effect of a second joint arthroplasty on metal ion levels after primary total hip arthroplasty. Am J Orthop (Belle Mead NJ) 42:E84-7
Levine, Brett R; Hsu, Andrew R; Skipor, Anastasia K et al. (2013) Ten-year outcome of serum metal ion levels after primary total hip arthroplasty: a concise follow-up of a previous report*. J Bone Joint Surg Am 95:512-8
Cooper, H John; Della Valle, Craig J; Berger, Richard A et al. (2012) Corrosion at the head-neck taper as a cause for adverse local tissue reactions after total hip arthroplasty. J Bone Joint Surg Am 94:1655-61
Mathew, Mathew T; Jacobs, Joshua J; Wimmer, Markus A (2012) Wear-corrosion synergism in a CoCrMo hip bearing alloy is influenced by proteins. Clin Orthop Relat Res 470:3109-17
Urban, Robert M; Hall, Deborah J; Della Valle, Craig et al. (2012) Successful long-term fixation and progression of osteolysis associated with first-generation cementless acetabular components retrieved post mortem. J Bone Joint Surg Am 94:1877-85
Laurent, Michel P; Pourzal, Robin; Fischer, Alfons et al. (2011) In vivo wear of a squeaky alumina-on-alumina hip prosthesis: a case report. J Bone Joint Surg Am 93:e27
Guyer, Richard D; Shellock, Jessica; MacLennan, Benjamin et al. (2011) Early failure of metal-on-metal artificial disc prostheses associated with lymphocytic reaction: diagnosis and treatment experience in four cases. Spine (Phila Pa 1976) 36:E492-7
Wright, Geoffrey; Sporer, Scott; Urban, Robert et al. (2010) Fracture of a modular femoral neck after total hip arthroplasty: a case report. J Bone Joint Surg Am 92:1518-21

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