Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR039705-05
Application #
3159912
Study Section
Pathobiochemistry Study Section (PBC)
Project Start
1989-02-01
Project End
1994-01-31
Budget Start
1993-02-01
Budget End
1994-01-31
Support Year
5
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
Schools of Dentistry
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Iwamoto, M; Yagami, K; Shapiro, I M et al. (1994) Retinoic acid is a major regulator of chondrocyte maturation and matrix mineralization. Microsc Res Tech 28:483-91
Lu Valle, P; Iwamoto, M; Fanning, P et al. (1993) Multiple negative elements in a gene that codes for an extracellular matrix protein, collagen X, restrict expression to hypertrophic chondrocytes. J Cell Biol 121:1173-9
Iwamoto, M; Shapiro, I M; Yagami, K et al. (1993) Retinoic acid induces rapid mineralization and expression of mineralization-related genes in chondrocytes. Exp Cell Res 207:413-20
Iwamoto, M; Golden, E B; Adams, S L et al. (1993) Responsiveness to retinoic acid changes during chondrocyte maturation. Exp Cell Res 205:213-24
Iwamoto, M; Yagami, K; Lu Valle, P et al. (1993) Expression and role of c-myc in chondrocytes undergoing endochondral ossification. J Biol Chem 268:9645-52
Adams, S L; Pallante, K M; Niu, Z et al. (1991) Rapid induction of type X collagen gene expression in cultured chick vertebral chondrocytes. Exp Cell Res 193:190-7
Pacifici, M; Golden, E B; Adams, S L et al. (1991) Cell hypertrophy and type X collagen synthesis in cultured articular chondrocytes. Exp Cell Res 192:266-70
Shapiro, I M; Leboy, P S; Tokuoka, T et al. (1991) Ascorbic acid regulates multiple metabolic activities of cartilage cells. Am J Clin Nutr 54:1209S-1213S
Pacifici, M; Golden, E B; Oshima, O et al. (1990) Hypertrophic chondrocytes. The terminal stage of differentiation in the chondrogenic cell lineage? Ann N Y Acad Sci 599:45-57
Adams, S L (1989) Collagen gene expression. Am J Respir Cell Mol Biol 1:161-8

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