Abstract

Severe explosive psoriasis and/or Reiter's syndrome may be an early cutaneous manifestation of HIV infection with a poor prognosis for development of AIDS - the acquired immunodeficiency syndrome. The association between psoriasis and HIV infection suggests an immunologic basis and possibly an infectious basis for the pathogenesis of psoriasis. Zidovudine therapy rapidly clears psoriasis and offers an important clinical model for understanding psoriasis and its observed association with AIDS. Akin biopsies and peripheral lymphocytes from HIV+ and HIV- psoriatics before and after zidovudine therapy will be studied for immunologic cell populations, DR antigen, and cytokine expression, and HIV infection using double immunoperoxidase and immunofluorescence antibodies, and riboprobes and 35S-UTP labeled riboprobe for in situ hybridization. HLA antigen associations in AIDS/psoriasis will be explored using Southern blotting to DR, DQ, and C locus cDNA probes. Analysis of AIDS associated psoriasis and the zidovudine induced remission at the molecular level should lead to a better understanding of the pathogenesis of psoriasis, its association with HIV infection, and better, safer therapy for psoriasis in general.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
1R01AR039915-01
Application #
3160154
Study Section
(ARR)
Project Start
1989-04-18
Project End
1992-03-31
Budget Start
1989-04-18
Budget End
1990-03-31
Support Year
1
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
University of Texas Health Science Center Houston
Department
Type
Schools of Medicine
DUNS #
City
Houston
State
TX
Country
United States
Zip Code
77225

  Publications

Breuer-McHam, J; Simpson, E; Dougherty, I et al. (2001) Activation of HIV in human skin by ultraviolet B radiation and its inhibition by NFkappaB blocking agents. Photochem Photobiol 74:805-10
Breuer-McHam, J N; Ledbetter, L S; Sarris, A H et al. (2000) Cytokine expression patterns distinguish HIV associated skin diseases. Exp Dermatol 9:341-50
Duvic, M; Friedman-Kien, A E; Looney, D J et al. (2000) Topical treatment of cutaneous lesions of acquired immunodeficiency syndrome-related Kaposi sarcoma using alitretinoin gel: results of phase 1 and 2 trials. Arch Dermatol 136:1461-9
Breuer-McHam, J; Marshall, G; Adu-Oppong, A et al. (1999) Alterations in HIV expression in AIDS patients with psoriasis or pruritus treated with phototherapy. J Am Acad Dermatol 40:48-60
Konstantinova, N V; Lemak, N A; Duong, D M et al. (1998) Artificial skin equivalent differentiation depends on fibroblast donor site: use of eyelid fibroblasts. Plast Reconstr Surg 101:385-91
Daliani, D; Ulmer, R A; Jackow, C et al. (1998) Tumor necrosis factor-alpha and interferon-gamma, but not HTLV-I tax, are likely factors in the epidermotropism of cutaneous T-cell lymphoma via induction of interferon-inducible protein-10. Leuk Lymphoma 29:315-28
Jackow, C; Puffer, N; Hordinsky, M et al. (1998) Alopecia areata and cytomegalovirus infection in twins: genes versus environment? J Am Acad Dermatol 38:418-25
Jackow, C M; Papadopoulos, E; Nelson, B et al. (1997) Follicular mucinosis associated with scarring alopecia, oligoclonal T-cell receptor V beta expansion, and Staphylococcus aureus: when does follicular mucinosis become mycosis fungoides? J Am Acad Dermatol 37:828-31
Jackow, C M; Cather, J C; Hearne, V et al. (1997) Association of erythrodermic cutaneous T-cell lymphoma, superantigen-positive Staphylococcus aureus, and oligoclonal T-cell receptor V beta gene expansion. Blood 89:32-40
Nagpal, S; Patel, S; Jacobe, H et al. (1997) Tazarotene-induced gene 2 (TIG2), a novel retinoid-responsive gene in skin. J Invest Dermatol 109:91-5

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