Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR040335-04
Application #
3160684
Study Section
Pathobiochemistry Study Section (PBC)
Project Start
1990-03-01
Project End
1995-02-28
Budget Start
1993-03-01
Budget End
1994-02-28
Support Year
4
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of Texas MD Anderson Cancer Center
Department
Type
Other Domestic Higher Education
DUNS #
001910777
City
Houston
State
TX
Country
United States
Zip Code
77030
Lefebvre, V; Behringer, R R; de Crombrugghe, B (2001) L-Sox5, Sox6 and Sox9 control essential steps of the chondrocyte differentiation pathway. Osteoarthritis Cartilage 9 Suppl A:S69-75
Lefebvre, V; de Crombrugghe, B (1998) Toward understanding SOX9 function in chondrocyte differentiation. Matrix Biol 16:529-40
Lefebvre, V; Huang, W; Harley, V R et al. (1997) SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene. Mol Cell Biol 17:2336-46
Zhao, Q; Behringer, R R; de Crombrugghe, B (1996) Prenatal folic acid treatment suppresses acrania and meroanencephaly in mice mutant for the Cart1 homeobox gene. Nat Genet 13:275-83
Lefebvre, V; Zhou, G; Mukhopadhyay, K et al. (1996) An 18-base-pair sequence in the mouse proalpha1(II) collagen gene is sufficient for expression in cartilage and binds nuclear proteins that are selectively expressed in chondrocytes. Mol Cell Biol 16:4512-23
Zhou, G; Garofalo, S; Mukhopadhyay, K et al. (1995) A 182 bp fragment of the mouse pro alpha 1(II) collagen gene is sufficient to direct chondrocyte expression in transgenic mice. J Cell Sci 108 ( Pt 12):3677-84
Mukhopadhyay, K; Lefebvre, V; Zhou, G et al. (1995) Use of a new rat chondrosarcoma cell line to delineate a 119-base pair chondrocyte-specific enhancer element and to define active promoter segments in the mouse pro-alpha 1(II) collagen gene. J Biol Chem 270:27711-9
Rossert, J; Eberspaecher, H; de Crombrugghe, B (1995) Separate cis-acting DNA elements of the mouse pro-alpha 1(I) collagen promoter direct expression of reporter genes to different type I collagen-producing cells in transgenic mice. J Cell Biol 129:1421-32
de Crombrugghe, B; Katzenstein, P; Mukhopadhyay, K et al. (1995) Transgenic mice with deficiencies in cartilage collagens: possible models for gene therapy. J Rheumatol Suppl 43:140-2
Lefebvre, V; Garofalo, S; de Crombrugghe, B (1995) Type X collagen gene expression in mouse chondrocytes immortalized by a temperature-sensitive simian virus 40 large tumor antigen. J Cell Biol 128:239-45

Showing the most recent 10 out of 24 publications