Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR040452-02
Application #
3160839
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Project Start
1990-04-01
Project End
1995-03-31
Budget Start
1991-04-01
Budget End
1992-03-31
Support Year
2
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Yale University
Department
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Fikrig, E; Barthold, S W; Chen, M et al. (1997) Protective antibodies develop, and murine Lyme arthritis regresses, in the absence of MHC class II and CD4+ T cells. J Immunol 159:5682-6
Fikrig, E; Barthold, S W; Sun, W et al. (1997) Borrelia burgdorferi P35 and P37 proteins, expressed in vivo, elicit protective immunity. Immunity 6:531-9
Fikrig, E; Barthold, S W; Chen, M et al. (1997) Lyme borreliosis in transgenic mice tolerant to OspA from Borrelia burgdorferi 25015. J Infect Dis 175:1000-3
Malawista, S E; Montgomery, R R; Van Blaricom, G (1996) Microbial killing by human neutrophil cytokineplasts: similar suppressive effects of reversible and irreversible inhibitors of nitric oxide synthase. J Leukoc Biol 60:753-7
Fikrig, E; Barthold, S W; Chen, M et al. (1996) Protective antibodies in murine Lyme disease arise independently of CD40 ligand. J Immunol 157:1-3
Montgomery, R R; Malawista, S E (1996) Entry of Borrelia burgdorferi into macrophages is end-on and leads to degradation in lysosomes. Infect Immun 64:2867-72
Anguita, J; Persing, D H; Rincon, M et al. (1996) Effect of anti-interleukin 12 treatment on murine lyme borreliosis. J Clin Invest 97:1028-34
Montgomery, R R; Malawista, S E; Feen, K J et al. (1996) Direct demonstration of antigenic substitution of Borrelia burgdorferi ex vivo: exploration of the paradox of the early immune response to outer surface proteins A and C in Lyme disease. J Exp Med 183:261-9
Fikrig, E; Tao, H; Barthold, S W et al. (1995) Selection of variant Borrelia burgdorferi isolates from mice immunized with outer surface protein A or B. Infect Immun 63:1658-62
Cretella, S; Gordon, S; Flavell, R A et al. (1995) Evaluation of a Lyme disease enzyme immunoassay using the 41-G fragment of flagellin. Eur J Clin Microbiol Infect Dis 14:609-13

Showing the most recent 10 out of 24 publications