Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
2R01AR040833-05
Application #
2080284
Study Section
Orthopedics and Musculoskeletal Study Section (ORTH)
Project Start
1992-07-10
Project End
2000-06-30
Budget Start
1996-07-20
Budget End
1997-06-30
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Anatomy/Cell Biology
Type
Schools of Dentistry
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Kitagaki, J; Iwamoto, M; Liu, J-G et al. (2003) Activation of beta-catenin-LEF/TCF signal pathway in chondrocytes stimulates ectopic endochondral ossification. Osteoarthritis Cartilage 11:36-43
Iwamoto, M; Kitagaki, J; Tamamura, Y et al. (2003) Runx2 expression and action in chondrocytes are regulated by retinoid signaling and parathyroid hormone-related peptide (PTHrP). Osteoarthritis Cartilage 11:6-15
Enomoto-Iwamoto, M; Nakamura, T; Aikawa, T et al. (2000) Hedgehog proteins stimulate chondrogenic cell differentiation and cartilage formation. J Bone Miner Res 15:1659-68
D'Angelo, M; Yan, Z; Nooreyazdan, M et al. (2000) MMP-13 is induced during chondrocyte hypertrophy. J Cell Biochem 77:678-93
Yagami, K; Suh, J Y; Enomoto-Iwamoto, M et al. (1999) Matrix GLA protein is a developmental regulator of chondrocyte mineralization and, when constitutively expressed, blocks endochondral and intramembranous ossification in the limb. J Cell Biol 147:1097-108
Koyama, E; Golden, E B; Kirsch, T et al. (1999) Retinoid signaling is required for chondrocyte maturation and endochondral bone formation during limb skeletogenesis. Dev Biol 208:375-91
Kirsch, T; Nah, H D; Shapiro, I M et al. (1997) Regulated production of mineralization-competent matrix vesicles in hypertrophic chondrocytes. J Cell Biol 137:1149-60
Kirsch, T; Nah, H D; Demuth, D R et al. (1997) Annexin V-mediated calcium flux across membranes is dependent on the lipid composition: implications for cartilage mineralization. Biochemistry 36:3359-67
D'Angelo, M; Pacifici, M (1997) Articular chondrocytes produce factors that inhibit maturation of sternal chondrocytes in serum-free agarose cultures: a TGF-beta independent process. J Bone Miner Res 12:1368-77
Koyama, E; Shimazu, A; Leatherman, J L et al. (1996) Expression of syndecan-3 and tenascin-C: possible involvement in periosteum development. J Orthop Res 14:403-12

Showing the most recent 10 out of 14 publications