Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR040840-06
Application #
2080294
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1991-04-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
De La Cruz, E M; Ostap, E M; Brundage, R A et al. (2000) Thymosin-beta(4) changes the conformation and dynamics of actin monomers. Biophys J 78:2516-27
Nagamalleswari, K; Safer, D (2000) Sequestered actin in chick embryo fibroblasts. Mol Cell Biochem 209:63-7
Niu, M; Nachmias, V T (2000) Increased resistance to apoptosis in cells overexpressing thymosin beta four: A role for focal adhesion kinase pp125FAK. Cell Adhes Commun 7:311-20
Devineni, N; Minamide, L S; Niu, M et al. (1999) A quantitative analysis of G-actin binding proteins and the G-actin pool in developing chick brain. Brain Res 823:129-40
Safer, D (1999) Undecagold cluster labeling of proteins at reactive cysteine residues. J Struct Biol 127:101-5
Golla, R; Philp, N; Safer, D et al. (1997) Co-ordinate regulation of the cytoskeleton in 3T3 cells overexpressing thymosin-beta4. Cell Motil Cytoskeleton 38:187-200
Niu, M Y; Mills, J C; Nachmias, V T (1997) Development of polarity in human erythroleukemia cells: roles of membrane ruffling and the centrosome. Cell Motil Cytoskeleton 36:203-15
Safer, D; Sosnick, T R; Elzinga, M (1997) Thymosin beta 4 binds actin in an extended conformation and contacts both the barbed and pointed ends. Biochemistry 36:5806-16
Safer, D; Chowrashi, P K (1997) Beta-thymosins from marine invertebrates: primary structure and interaction with actin. Cell Motil Cytoskeleton 38:163-71
Sanger, J M; Golla, R; Safer, D et al. (1995) Increasing intracellular concentrations of thymosin beta 4 in PtK2 cells: effects on stress fibers, cytokinesis, and cell spreading. Cell Motil Cytoskeleton 31:307-22

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