Bone mineral density (BMD) before menopause is hypothesed to be important in providing sufficient bone mineral reserve so that bone loss associated with menopause and aging does not leave the individual compromised and at substantial risk for osteoporotic fracture. However, our recent investigation suggests that bone loss may occur prior to menopause. Therefore, we propose to examine premenopausal BMD levels and relate BMD changes to concurrently characterized hormones associated with approaching climacteric. This prospective longitudinal study can be undertaken efficiently because femoral bone mineral density already has been measured in a large cohort of premenopausal women in 1988.
Specific aims are: 1.To measure BMD by dual-photon densitometry and dual x-ray densitometry in 383 women, aged 30-40 at baseline, over an 8-year period with 5 measurements (1988, 1992, 1993, 1994, and 1995). 2.If premenopausal bone loss occurs, to describe the loss in terms of age and rate for all measured bone sites including the spine, proximal femur and total body skeleton. 3.To characterize estradiol, testosterone and follicle stimulating hormone annually and simultaneously with BMD measurement and to examine the prognostic impact of changes in ovarian function on premenopausal BMD. 4.To determine if the relationships observed between measures of ovarian function and BMD remain consistent following adjustment for diet, body composition, and physical activity? Data analysis methodology will include analysis of variance, multiple variable regression (including growth curve analysis) and logistic regression. This study will contribute to the understanding of bone- dynamics in the perimenopause and help determine if there is accelerated bone loss associated with the premenopausal decline in ovarian function. It may identify that women at risk for accelerated premenopausal loss of bone mass could benefit from premenopausal administration of estrogens, calcium supplementation or exercise therapy.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR040888-03
Application #
2080321
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Project Start
1992-04-15
Project End
1996-03-31
Budget Start
1994-04-01
Budget End
1995-03-31
Support Year
3
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Rillamas-Sun, Eileen; Harlow, Siobán D; Randolph Jr, John F (2014) Grandmothers' smoking in pregnancy and grandchildren's birth weight: comparisons by grandmother birth cohort. Matern Child Health J 18:1691-8
Rillamas-Sun, Eileen; Sowers, MaryFran R; Harlow, Sioban D et al. (2012) The relationship of birth weight with longitudinal changes in body composition in adult women. Obesity (Silver Spring) 20:463-5
Griffin, Flojaune C; Gadegbeku, Crystal A; Sowers, MaryFran R (2011) Vitamin D and subsequent systolic hypertension among women. Am J Hypertens 24:316-21
Sowers, MaryFran R; Zheng, Huiyong; Jannausch, Mary L et al. (2010) Amount of bone loss in relation to time around the final menstrual period and follicle-stimulating hormone staging of the transmenopause. J Clin Endocrinol Metab 95:2155-62
Sowers, MaryFran R; McConnell, Daniel; Yosef, Matheos et al. (2010) Relating smoking, obesity, insulin resistance, and ovarian biomarker changes to the final menstrual period. Ann N Y Acad Sci 1204:95-103
Sowers, M F R; Zheng, H; McConnell, D et al. (2009) Testosterone, sex hormone-binding globulin and free androgen index among adult women: chronological and ovarian aging. Hum Reprod 24:2276-85
Sowers, MaryFran R; Zheng, Huiyong; McConnell, Daniel et al. (2008) Estradiol rates of change in relation to the final menstrual period in a population-based cohort of women. J Clin Endocrinol Metab 93:3847-52
Sowers, MaryFran R; Eyvazzadeh, Aimee D; McConnell, Daniel et al. (2008) Anti-mullerian hormone and inhibin B in the definition of ovarian aging and the menopause transition. J Clin Endocrinol Metab 93:3478-83
Sowers, MaryFran R; Zheng, Huiyong; McConnell, Daniel et al. (2008) Follicle stimulating hormone and its rate of change in defining menopause transition stages. J Clin Endocrinol Metab 93:3958-64
Sowers, M F; Yosef, M; Jamadar, D et al. (2008) BMI vs. body composition and radiographically defined osteoarthritis of the knee in women: a 4-year follow-up study. Osteoarthritis Cartilage 16:367-72

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