Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR040994-04
Application #
2080387
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1991-09-01
Project End
1996-07-14
Budget Start
1994-09-01
Budget End
1996-07-14
Support Year
4
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of Kansas
Department
Biochemistry
Type
Schools of Medicine
DUNS #
016060860
City
Kansas City
State
KS
Country
United States
Zip Code
66160
Santamaria, Salvatore; Fedorov, Oleg; McCafferty, John et al. (2017) Development of a monoclonal anti-ADAMTS-5 antibody that specifically blocks the interaction with LRP1. MAbs 9:595-602
Chanalaris, Anastasios; Doherty, Christine; Marsden, Brian D et al. (2017) Suramin Inhibits Osteoarthritic Cartilage Degradation by Increasing Extracellular Levels of Chondroprotective Tissue Inhibitor of Metalloproteinases 3. Mol Pharmacol 92:459-468
Yamamoto, Kazuhiro; Santamaria, Salvatore; Botkjaer, Kenneth A et al. (2017) Inhibition of Shedding of Low-Density Lipoprotein Receptor-Related Protein 1 Reverses Cartilage Matrix Degradation in Osteoarthritis. Arthritis Rheumatol 69:1246-1256
Watanabe, Kenta; Hirata, Michiko; Tominari, Tsukasa et al. (2016) BA321, a novel carborane analog that binds to androgen and estrogen receptors, acts as a new selective androgen receptor modulator of bone in male mice. Biochem Biophys Res Commun 478:279-285
Zou, Haiyin; Wu, Ying; Brew, Keith (2016) Thermodynamic Basis of Selectivity in the Interactions of Tissue Inhibitors of Metalloproteinases N-domains with Matrix Metalloproteinases-1, -3, and -14. J Biol Chem 291:11348-58
Doherty, Christine M; Visse, Robert; Dinakarpandian, Deendayal et al. (2016) Engineered Tissue Inhibitor of Metalloproteinases-3 Variants Resistant to Endocytosis Have Prolonged Chondroprotective Activity. J Biol Chem 291:22160-22172
Watanabe, Kenta; Hirata, Michiko; Tominari, Tsukasa et al. (2016) The MET/Vascular Endothelial Growth Factor Receptor (VEGFR)-targeted Tyrosine Kinase Inhibitor Also Attenuates FMS-dependent Osteoclast Differentiation and Bone Destruction Induced by Prostate Cancer. J Biol Chem 291:20891-20899
Yamamoto, Kazuhiro; Okano, Hiroshi; Miyagawa, Wakako et al. (2016) MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1. Matrix Biol 56:57-73
Ismail, Heba M; Yamamoto, Kazuhiro; Vincent, Tonia L et al. (2015) Interleukin-1 Acts via the JNK-2 Signaling Pathway to Induce Aggrecan Degradation by Human Chondrocytes. Arthritis Rheumatol 67:1826-36
Santamaria, Salvatore; Yamamoto, Kazuhiro; Botkjaer, Kenneth et al. (2015) Antibody-based exosite inhibitors of ADAMTS-5 (aggrecanase-2). Biochem J 471:391-401

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