Motor Denervation, Muscle Atrophy, and Insulin

Lawrence, John C.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
• Type: Research Project (R01)
• Project #: 7R01AR041180-06
• Application #: 2080538
• Study Section: Medical Biochemistry Study Section (MEDB)
• Project Start: 1992-02-01
• Project End: 2001-06-30
• Budget Start: 1996-07-17
• Budget End: 1997-06-30
• Support Year: 6
• Fiscal Year: 1996

Institution

• Name: University of Virginia
• Department: Pharmacology
• Type: Schools of Medicine
• DUNS #: 001910777
• City: Charlottesville
• State: VA
• Country: United States
• Zip Code: 22904

Publications

Reynolds 4th, Thomas H; Bodine, Sue C; Lawrence Jr, John C (2002) Control of Ser2448 phosphorylation in the mammalian target of rapamycin by insulin and skeletal muscle load. J Biol Chem 277:17657-62

Mothe-Satney, I; Brunn, G J; McMahon, L P et al. (2000) Mammalian target of rapamycin-dependent phosphorylation of PHAS-I in four (S/T)P sites detected by phospho-specific antibodies. J Biol Chem 275:33836-43

Scrimgeour, A G; Allen, P B; Fienberg, A A et al. (1999) Inhibitor-1 is not required for the activation of glycogen synthase by insulin in skeletal muscle. J Biol Chem 274:20949-52

Xu, G; Kwon, G; Marshall, C A et al. (1998) Branched-chain amino acids are essential in the regulation of PHAS-I and p70 S6 kinase by pancreatic beta-cells. A possible role in protein translation and mitogenic signaling. J Biol Chem 273:28178-84

Scott, P H; Brunn, G J; Kohn, A D et al. (1998) Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway. Proc Natl Acad Sci U S A 95:7772-7

Scott, P H; Lawrence Jr, J C (1998) Attenuation of mammalian target of rapamycin activity by increased cAMP in 3T3-L1 adipocytes. J Biol Chem 273:34496-501

Lin, T A; Lawrence Jr, J C (1997) Control of PHAS-I phosphorylation in 3T3-L1 adipocytes: effects of inhibiting protein phosphatases and the p70S6K signalling pathway. Diabetologia 40 Suppl 2:S18-24

Brunn, G J; Fadden, P; Haystead, T A et al. (1997) The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus. J Biol Chem 272:32547-50

Lawrence Jr, J C; Abraham, R T (1997) PHAS/4E-BPs as regulators of mRNA translation and cell proliferation. Trends Biochem Sci 22:345-9

Kimball, S R; Jurasinski, C V; Lawrence Jr, J C et al. (1997) Insulin stimulates protein synthesis in skeletal muscle by enhancing the association of eIF-4E and eIF-4G. Am J Physiol 272:C754-9