Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR042025-03
Application #
2081220
Study Section
Orthopedics and Musculoskeletal Study Section (ORTH)
Project Start
1994-04-01
Project End
1997-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Orthopedics
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Cao, M; Stefanovic-Racic, M; Georgescu, H I et al. (2000) Does nitric oxide help explain the differential healing capacity of the anterior cruciate, posterior cruciate, and medial collateral ligaments? Am J Sports Med 28:176-82
Xu, Z; Buckley, M J; Evans, C H et al. (2000) Cyclic tensile strain acts as an antagonist of IL-1 beta actions in chondrocytes. J Immunol 165:453-60
Studer, R K; Georgescu, H I; Miller, L A et al. (1999) Inhibition of transforming growth factor beta production by nitric oxide-treated chondrocytes: implications for matrix synthesis. Arthritis Rheum 42:248-57
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Kang, J D; Stefanovic-Racic, M; McIntyre, L A et al. (1997) Toward a biochemical understanding of human intervertebral disc degeneration and herniation. Contributions of nitric oxide, interleukins, prostaglandin E2, and matrix metalloproteinases. Spine (Phila Pa 1976) 22:1065-73
Cao, M; Westerhausen-Larson, A; Niyibizi, C et al. (1997) Nitric oxide inhibits the synthesis of type-II collagen without altering Col2A1 mRNA abundance: prolyl hydroxylase as a possible target. Biochem J 324 ( Pt 1):305-10

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