Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR042438-02
Application #
2006342
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1996-03-01
Project End
1997-01-31
Budget Start
1996-12-01
Budget End
1997-01-31
Support Year
2
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Kuhn, Klaus; Lotz, Martin (2003) Mechanisms of sodium nitroprusside-induced death in human chondrocytes. Rheumatol Int 23:241-7
Kuhn, Klaus; Shikhman, Alexander R; Lotz, Martin (2003) Role of nitric oxide, reactive oxygen species, and p38 MAP kinase in the regulation of human chondrocyte apoptosis. J Cell Physiol 197:379-87
Kuhn, K; Lotz, M (2001) Regulation of CD95 (Fas/APO-1)-induced apoptosis in human chondrocytes. Arthritis Rheum 44:1644-53
Kuhn, K; Hashimoto, S; Lotz, M (2000) IL-1 beta protects human chondrocytes from CD95-induced apoptosis. J Immunol 164:2233-9
Hashimoto, S; Takahashi, K; Ochs, R L et al. (1999) Nitric oxide production and apoptosis in cells of the meniscus during experimental osteoarthritis. Arthritis Rheum 42:2123-31
Lotz, M (1999) The role of nitric oxide in articular cartilage damage. Rheum Dis Clin North Am 25:269-82
Hashimoto, S; Takahashi, K; Amiel, D et al. (1998) Chondrocyte apoptosis and nitric oxide production during experimentally induced osteoarthritis. Arthritis Rheum 41:1266-74
Hashimoto, S; Ochs, R L; Komiya, S et al. (1998) Linkage of chondrocyte apoptosis and cartilage degradation in human osteoarthritis. Arthritis Rheum 41:1632-8
Geng, Y; Zhou, L; Thompson, W J et al. (1998) Cyclic GMP and cGMP-binding phosphodiesterase are required for interleukin-1-induced nitric oxide synthesis in human articular chondrocytes. J Biol Chem 273:27484-91
Hashimoto, S; Setareh, M; Ochs, R L et al. (1997) Fas/Fas ligand expression and induction of apoptosis in chondrocytes. Arthritis Rheum 40:1749-55

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