Autoantibodies and Immunodysregulation in Sle

Fu, Shu Man

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
• Type: Research Project (R01)
• Project #: 3R01AR042465-03S1
• Application #: 2081746
• Study Section: Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
• Project Start: 1994-09-30
• Project End: 1999-08-31
• Budget Start: 1996-09-01
• Budget End: 1997-08-31
• Support Year: 3
• Fiscal Year: 1996

Institution

• Name: University of Virginia
• Department: Internal Medicine/Medicine
• Type: Schools of Medicine
• DUNS #: 001910777
• City: Charlottesville
• State: VA
• Country: United States
• Zip Code: 22904

Publications

Waters, Samuel T; McDuffie, Marcia; Bagavant, Harini et al. (2004) Breaking tolerance to double stranded DNA, nucleosome, and other nuclear antigens is not required for the pathogenesis of lupus glomerulonephritis. J Exp Med 199:255-64

Paisansinsup, Tawatchai; Deshmukh, Umesh S; Chowdhary, Vaidehi R et al. (2002) HLA class II influences the immune response and antibody diversification to Ro60/Sjogren's syndrome-A: heightened antibody responses and epitope spreading in mice expressing HLA-DR molecules. J Immunol 168:5876-84

Waters, S T; Fu, S M; Gaskin, F et al. (2001) NZM2328: a new mouse model of systemic lupus erythematosus with unique genetic susceptibility loci. Clin Immunol 100:372-83

Deshmukh, U S; Lewis, J E; Gaskin, F et al. (2000) Ro60 peptides induce antibodies to similar epitopes shared among lupus-related autoantigens. J Immunol 164:6655-61

Deshmukh, U S; Lewis, J E; Gaskin, F et al. (1999) Immune responses to Ro60 and its peptides in mice. I. The nature of the immunogen and endogenous autoantigen determine the specificities of the induced autoantibodies. J Exp Med 189:531-40