Nitric Oxide, Osteoclasts and Metabolic Bone Disease - Philip Osdoby

Abstract

Funding Agency

Agency: National Institute of Health (NIH)
Institute: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type: Research Project (R01)
Project #: 1R01AR042715-01A3
Application #: 2082147
Study Section: Orthopedics and Musculoskeletal Study Section (ORTH)

Project Start: 1996-04-01
Project End: 2000-03-31
Budget Start: 1996-04-01
Budget End: 1997-03-31
Support Year: 1
Fiscal Year: 1996
Total Cost
Indirect Cost

Institution

Name: Washington University
Department: Biology
Type: Schools of Arts and Sciences
DUNS #: 062761671

City: Saint Louis
State: MO
Country: United States
Zip Code: 63130

Related projects


NIH 2004 R01 AR	Nitric Oxide, Osteoclasts and Metabolic Bone Disease Osdoby, Philip A. / Washington University	$217,140
NIH 2003 R01 AR	Nitric Oxide, Osteoclasts and Metabolic Bone Disease Osdoby, Philip A. / Washington University	$217,140
NIH 2002 R01 AR	Nitric Oxide, Osteoclasts and Metabolic Bone Disease Osdoby, Philip A. / Washington University	$217,140
NIH 2001 R01 AR	Nitric Oxide, Osteoclasts and Metabolic Bone Disease Osdoby, Philip A. / Washington University	$217,140
NIH 2000 R01 AR	Nitric Oxide, Osteoclasts and Metabolic Bone Disease Osdoby, Philip A. / Washington University	$217,669
NIH 1999 R01 AR	Nitric Oxide, Osteoclasts and Metabolic Bone Disease Osdoby, Philip A. / Washington University
NIH 1998 R01 AR	Nitric Oxide, Osteoclasts and Metabolic Bone Disease Osdoby, Philip A. / Washington University
NIH 1997 R01 AR	Nitric Oxide, Osteoclasts and Metabolic Bone Disease Osdoby, Philip A. / Washington University
NIH 1996 R01 AR	Nitric Oxide, Osteoclasts and Metabolic Bone Disease Osdoby, Philip A. / Washington University

Publications

Collin-Osdoby, Patricia; Osdoby, Philip (2012) Isolation and culture of primary chicken osteoclasts. Methods Mol Biol 816:119-43

Zheng, Hong; Yu, Xuefeng; Collin-Osdoby, Patricia et al. (2006) RANKL stimulates inducible nitric-oxide synthase expression and nitric oxide production in developing osteoclasts. An autocrine negative feedback mechanism triggered by RANKL-induced interferon-beta via NF-kappaB that restrains osteoclastogenesis and bone J Biol Chem 281:15809-20

Collin-Osdoby, Patricia; Anderson, Fred; Osdoby, Philip (2003) Primary isolation and culture of chicken osteoclasts. Methods Mol Med 80:65-88

Collin-Osdoby, P; Rothe, L; Bekker, S et al. (2000) Decreased nitric oxide levels stimulate osteoclastogenesis and bone resorption both in vitro and in vivo on the chick chorioallantoic membrane in association with neoangiogenesis. J Bone Miner Res 15:474-88

Collin-Osdoby, P; Li, L; Rothe, L et al. (1998) Inhibition of avian osteoclast bone resorption by monoclonal antibody 121F: a mechanism involving the osteoclast free radical system. J Bone Miner Res 13:67-78

Sunyer, T; Rothe, L; Kirsch, D et al. (1997) Ca2+ or phorbol ester but not inflammatory stimuli elevate inducible nitric oxide synthase messenger ribonucleic acid and nitric oxide (NO) release in avian osteoclasts: autocrine NO mediates Ca2+-inhibited bone resorption. Endocrinology 138:2148-62

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