Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
2R01AR043396-04A1
Application #
6332084
Study Section
Cell Development and Function Integrated Review Group (CDF)
Program Officer
Lymn, Richard W
Project Start
1996-04-01
Project End
2006-03-31
Budget Start
2001-04-09
Budget End
2002-03-31
Support Year
4
Fiscal Year
2001
Total Cost
$311,176
Indirect Cost
Name
San Diego State University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
073371346
City
San Diego
State
CA
Country
United States
Zip Code
92182
Cammarato, Anthony; Li, Xiaochuan Edward; Reedy, Mary C et al. (2011) Structural basis for myopathic defects engendered by alterations in the myosin rod. J Mol Biol 414:477-84
Miller, Mark S; Dambacher, Corey M; Knowles, Aileen F et al. (2009) Alternative S2 hinge regions of the myosin rod affect myofibrillar structure and myosin kinetics. Biophys J 96:4132-43
Cammarato, Anthony; Dambacher, Corey M; Knowles, Aileen F et al. (2008) Myosin transducer mutations differentially affect motor function, myofibril structure, and the performance of skeletal and cardiac muscles. Mol Biol Cell 19:553-62
Suggs, Jennifer A; Cammarato, Anthony; Kronert, William A et al. (2007) Alternative S2 hinge regions of the myosin rod differentially affect muscle function, myofibril dimensions and myosin tail length. J Mol Biol 367:1312-29
Hao, Yudong; Miller, Mark S; Swank, Douglas M et al. (2006) Passive stiffness in Drosophila indirect flight muscle reduced by disrupting paramyosin phosphorylation, but not by embryonic myosin S2 hinge substitution. Biophys J 91:4500-6
Melkani, Girish C; Cammarato, Anthony; Bernstein, Sanford I (2006) alphaB-crystallin maintains skeletal muscle myosin enzymatic activity and prevents its aggregation under heat-shock stress. J Mol Biol 358:635-45
Liu, Hongjun; Miller, Mark S; Swank, Douglas M et al. (2005) Paramyosin phosphorylation site disruption affects indirect flight muscle stiffness and power generation in Drosophila melanogaster. Proc Natl Acad Sci U S A 102:10522-7
Hao, Yudong; Bernstein, Sanford I; Pollack, Gerald H (2004) Passive stiffness of Drosophila IFM myofibrils: a novel, high accuracy measurement method. J Muscle Res Cell Motil 25:359-66
Liu, Hongjun; Mardahl-Dumesnil, Michelle; Sweeney, Sean T et al. (2003) Drosophila paramyosin is important for myoblast fusion and essential for myofibril formation. J Cell Biol 160:899-908
Zhang, S; Bernstein, S I (2001) Spatially and temporally regulated expression of myosin heavy chain alternative exons during Drosophila embryogenesis. Mech Dev 101:35-45

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