Using infrared tomography (IRT), the broad, long term objective of the proposed research is the development of a three-dimensional tomographic reconstruction algorithm (TRA) as a means to determine the: (1) initial space-dependent temperature increase in subsurface chromophores (delta T CHR(zetu,eta,zetu,t=0)) immediately following pulsed laser exposure; and (2) depths and physical dimensions of discrete subsurface chromophores. Although our research is being shared with workers in a variety of disciplines, and pertinent to many clinical applications involving laser-induced photothermal mechanisms, the principal investigator and colleagues are particularly interested in addressing the problems associated with determination of the initial space- dependent temperature increase in subsurface chromophores in human skin in general, and port wine stain (PWS) blood vessels in particular. The project will be conducted in the combined basic research laboratories and outpatient clinic at the Beckman Laser Institute and Medical Clinic, University of California, Irvine. Design and development of the tomographic reconstruction algorithm (TRA) will be guided by studies proposed at four levels: (1) in vitro phantom collagen film model chromophore experimentation; (2) in vivo studies using the chick chorioallantoic membrane (CAM); (3) studies on the chicken comb animal model; and (4) clinical trials in PWS patients.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR043419-04
Application #
6171493
Study Section
Special Emphasis Panel (ZRG7-DMG (01))
Program Officer
Moshell, Alan N
Project Start
1997-09-01
Project End
2003-08-31
Budget Start
2000-09-01
Budget End
2003-08-31
Support Year
4
Fiscal Year
2000
Total Cost
$229,586
Indirect Cost
Name
University of California Irvine
Department
Surgery
Type
Schools of Medicine
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697
Jung, Byungjo; Choi, Bernard; Durkin, Anthony J et al. (2004) Characterization of port wine stain skin erythema and melanin content using cross-polarized diffuse reflectance imaging. Lasers Surg Med 34:174-81
Choi, Bernard; Majaron, Boris; Nelson, J Stuart (2004) Computational model to evaluate port wine stain depth profiling using pulsed photothermal radiometry. J Biomed Opt 9:299-307
Viator, John A; Choi, Bernard; Ambrose, Martin et al. (2003) In vivo port-wine stain depth determination with a photoacoustic probe. Appl Opt 42:3215-24
Viator, John A; Choi, Bernard; Peavy, George M et al. (2003) Spectra from 2.5-15 microm of tissue phantom materials, optical clearing agents and ex vivo human skin: implications for depth profiling of human skin. Phys Med Biol 48:N15-24
Diaz, Sergio H; Nelson, J Stuart; Wong, Brian J F (2003) Rate process analysis of thermal damage in cartilage. Phys Med Biol 48:19-29
Edris, Ahmad; Choi, Bernard; Aguilar, Guillermo et al. (2003) Measurements of laser light attenuation following cryogen spray cooling spurt termination. Lasers Surg Med 32:143-7
Gaon, M D; Ho, K-H K; Wong, B J F (2003) Measurement of the elastic modulus of porcine septal cartilage specimens following Nd: YAG laser treatment. Lasers Med Sci 18:148-53
Aguilar, Guillermo; Diaz, Sergio H; Lavernia, Enrique J et al. (2002) Cryogen spray cooling efficiency: improvement of port wine stain laser therapy through multiple-intermittent cryogen spurts and laser pulses. Lasers Surg Med 31:27-35
Viator, John A; Au, Gigi; Paltauf, Guenther et al. (2002) Clinical testing of a photoacoustic probe for port wine stain depth determination. Lasers Surg Med 30:141-8
Telenko, Sergev A; Vargas, Gracie; Nelson, J Stuart et al. (2002) Coherent thermal wave imaging of subsurface chromophores in biological materials. Phys Med Biol 47:657-71

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