Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
1R01AR043621-01A1
Application #
2083349
Study Section
Human Embryology and Development Subcommittee 1 (HED)
Project Start
1996-04-01
Project End
2000-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Pathology
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Takahara, Kazuhiko; Schwarze, Ulrike; Imamura, Yasutada et al. (2002) Order of intron removal influences multiple splice outcomes, including a two-exon skip, in a COL5A1 acceptor-site mutation that results in abnormal pro-alpha1(V) N-propeptides and Ehlers-Danlos syndrome type I. Am J Hum Genet 71:451-65
Uzel, M I; Scott, I C; Babakhanlou-Chase, H et al. (2001) Multiple bone morphogenetic protein 1-related mammalian metalloproteinases process pro-lysyl oxidase at the correct physiological site and control lysyl oxidase activation in mouse embryo fibroblast cultures. J Biol Chem 276:22537-43
Imamura, Y; Scott, I C; Greenspan, D S (2000) The pro-alpha3(V) collagen chain. Complete primary structure, expression domains in adult and developing tissues, and comparison to the structures and expression domains of the other types V and XI procollagen chains. J Biol Chem 275:8749-59
Mott, J D; Thomas, C L; Rosenbach, M T et al. (2000) Post-translational proteolytic processing of procollagen C-terminal proteinase enhancer releases a metalloproteinase inhibitor. J Biol Chem 275:1384-90
Scott, I C; Steiglitz, B M; Clark, T G et al. (2000) Spatiotemporal expression patterns of mammalian chordin during postgastrulation embryogenesis and in postnatal brain. Dev Dyn 217:449-56
Amano, S; Scott, I C; Takahara, K et al. (2000) Bone morphogenetic protein 1 is an extracellular processing enzyme of the laminin 5 gamma 2 chain. J Biol Chem 275:22728-35
Schwarze, U; Atkinson, M; Hoffman, G G et al. (2000) Null alleles of the COL5A1 gene of type V collagen are a cause of the classical forms of Ehlers-Danlos syndrome (types I and II). Am J Hum Genet 66:1757-65
Scott, I C; Imamura, Y; Pappano, W N et al. (2000) Bone morphogenetic protein-1 processes probiglycan. J Biol Chem 275:30504-11
Scott, I C; Blitz, I L; Pappano, W N et al. (1999) Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis. Dev Biol 213:283-300
Scott, I C; Clark, T G; Takahara, K et al. (1999) Assignment of TLL1 and TLL2, which encode human BMP-1/Tolloid-related metalloproteases, to chromosomes 4q32-->q33 and 10q23-->q24 and assignment of murine Tll2 to chromosome 19. Cytogenet Cell Genet 86:64-5

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