Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR043718-02
Application #
2083463
Study Section
AIDS and Related Research Study Section 1 (ARRA)
Project Start
1995-09-30
Project End
1998-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Washington State University
Department
Veterinary Sciences
Type
Schools of Veterinary Medicine
DUNS #
041485301
City
Pullman
State
WA
Country
United States
Zip Code
99164
Murphy, Brian; Jasmer, Douglas P; White, Stephen N et al. (2007) Localization of a TNF-activated transcription site and interactions with the gamma activated site within the CAEV U3 70 base pair repeat. Virology 364:196-207
Murphy, Brian G; Hotzel, Isidro; Jasmer, Douglas P et al. (2006) TNFalpha and GM-CSF-induced activation of the CAEV promoter is independent of AP-1. Virology 352:188-99
Hotzel, Isidro; Cheevers, William P (2005) Mutations increasing exposure of a receptor binding site epitope in the soluble and oligomeric forms of the caprine arthritis-encephalitis lentivirus envelope glycoprotein. Virology 339:261-72
Trujillo, Jessie D; Hotzel, Kathy J; Snekvik, Kevin R et al. (2004) Antibody response to the surface envelope of caprine arthritis-encephalitis lentivirus: disease status is predicted by SU antibody isotype. Virology 325:129-36
Trujillo, J D; Kumpula-McWhirter, N M; Hotzel, K J et al. (2004) Glycosylation of immunodominant linear epitopes in the carboxy-terminal region of the caprine arthritis-encephalitis virus surface envelope enhances vaccine-induced type-specific and cross-reactive neutralizing antibody responses. J Virol 78:9190-202
Hotzel, Isidro; Cheevers, William P (2003) Caprine arthritis-encephalitis virus envelope surface glycoprotein regions interacting with the transmembrane glycoprotein: structural and functional parallels with human immunodeficiency virus type 1 gp120. J Virol 77:11578-87
Cheevers, W P; Snekvik, K R; Trujillo, J D et al. (2003) Prime-boost vaccination with plasmid DNA encoding caprine-arthritis encephalitis lentivirus env and viral SU suppresses challenge virus and development of arthritis. Virology 306:116-25
Hotzel, Isidro; Cheevers, William P (2002) A maedi-visna virus strain K1514 receptor gene is located in sheep chromosome 3p and the syntenic region of human chromosome 2. J Gen Virol 83:1759-64
Hotzel, Isidro; Cheevers, William (2002) Differential receptor usage of small ruminant lentiviruses in ovine and caprine cells: host range but not cytopathic phenotype is determined by receptor usage. Virology 301:21-31
Hotzel, I; Cheevers, W P (2001) Host range of small-ruminant lentivirus cytopathic variants determined with a selectable caprine arthritis- encephalitis virus pseudotype system. J Virol 75:7384-91

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