Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
1R01AR043731-01A1
Application #
2083477
Study Section
Orthopedics and Musculoskeletal Study Section (ORTH)
Project Start
1996-07-15
Project End
2000-06-30
Budget Start
1996-07-15
Budget End
1997-06-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Washington University
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Sierra, Oscar L; Towler, Dwight A (2010) Runx2 trans-activation mediated by the MSX2-interacting nuclear target requires homeodomain interacting protein kinase-3. Mol Endocrinol 24:1478-97
Towler, Dwight A (2008) Oxidation, inflammation, and aortic valve calcification peroxide paves an osteogenic path. J Am Coll Cardiol 52:851-4
Cheng, Su-Li; Shao, Jian-Su; Cai, Jun et al. (2008) Msx2 exerts bone anabolism via canonical Wnt signaling. J Biol Chem 283:20505-22
Towler, Dwight A (2007) Calciotropic hormones and arterial physiology: ""D""-lightful insights. J Am Soc Nephrol 18:369-73
Towler, Dwight A (2007) Imaging aortic matrix metabolism: mirabile visu! Circulation 115:297-9
Towler, Dwight A; Shao, Jian-Su; Cheng, Su-Li et al. (2006) Osteogenic regulation of vascular calcification. Ann N Y Acad Sci 1068:327-33
Towler, Dwight A (2005) Inorganic pyrophosphate: a paracrine regulator of vascular calcification and smooth muscle phenotype. Arterioscler Thromb Vasc Biol 25:651-4
Shao, Jian-Su; Cheng, Su-Li; Pingsterhaus, Joyce M et al. (2005) Msx2 promotes cardiovascular calcification by activating paracrine Wnt signals. J Clin Invest 115:1210-20
Towler, Dwight A (2004) Vascular calcification in ESRD: Another cloud appears in the perfect storm--but highlights a silver lining? Kidney Int 66:2467-8
Sierra, Oscar L; Cheng, Su-Li; Loewy, Arleen P et al. (2004) MINT, the Msx2 interacting nuclear matrix target, enhances Runx2-dependent activation of the osteocalcin fibroblast growth factor response element. J Biol Chem 279:32913-23

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