Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR043967-02
Application #
2083713
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Project Start
1995-09-30
Project End
1998-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Wayne State University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48202
Jiang, Kaiyu; Chen, Yanmin; Jarvis, James N (2004) Cord blood and adult T cells show different responses to C1q-bearing immune complexes. Cell Immunol 229:62-7
Jiang, K; Chen, Y; Xu, C-S et al. (2003) T cell activation by soluble C1q-bearing immune complexes: implications for the pathogenesis of rheumatoid arthritis. Clin Exp Immunol 131:61-7
Xiao, S; Xu, C; Jarvis, J N (2001) C1q-bearing immune complexes induce IL-8 secretion in human umbilical vein endothelial cells (HUVEC) through protein tyrosine kinase- and mitogen-activated protein kinase-dependent mechanisms: evidence that the 126 kD phagocytic C1q receptor mediates immu Clin Exp Immunol 125:360-7
Jarvis, J N; Xu, C; Wang, W et al. (1999) Immune complex size and complement regulate cytokine production by peripheral blood mononuclear cells. Clin Immunol 93:274-82
Amit, A; Kindzelskii, A L; Zanoni, J et al. (1999) Complement deposition on immune complexes reduces the frequencies of metabolic, proteolytic, and superoxide oscillations of migrating neutrophils. Cell Immunol 194:47-53
Jarvis, J N (1998) Pathogenesis and mechanisms of inflammation in the childhood rheumatic diseases. Curr Opin Rheumatol 10:459-67
Schwartz, M M; Simpson, P; Kerr, K L et al. (1997) Juvenile rheumatoid arthritis in African Americans. J Rheumatol 24:1826-9
Jarvis, J N; Zhao, L; Xu, C S et al. (1997) Constitutive expression c-fos, c-jun, and NF kappa B mRNA is in nucleated fetal blood cells and up-regulation of c-fos and c-jun with anti-CD3 stimulation. Biol Neonate 72:329-36
Jarvis, J N; Wang, W; Moore, H T et al. (1997) In vitro induction of proinflammatory cytokine secretion by juvenile rheumatoid arthritis synovial fluid immune complexes. Arthritis Rheum 40:2039-46
Jarvis, J N; Zhao, L; Moore, H T et al. (1996) Regulation of cytokine mRNA expression in activated lymphocytes by human choriocarcinoma JAR cells. Cell Immunol 168:251-7