Marrow Stromal Cells and Gene Therapy of Bone Diseases

Prockop, Darwin Johnson

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
• Type: Research Project (R01)
• Project #: 7R01AR044210-03
• Application #: 6032273
• Study Section: Special Emphasis Panel (ZRG4-ORTH (05))
• Project Start: 1997-04-18
• Project End: 2001-03-31
• Budget Start: 1998-11-11
• Budget End: 1999-03-31
• Support Year: 3
• Fiscal Year: 1998

Institution

• Name: Mcp Hahnemann University
• Type: Schools of Medicine
• City: Philadelphia
• State: PA
• Country: United States
• Zip Code: 19102

Publications

Oskowitz, Adam Z; Penfornis, Patrice; Tucker, Alan et al. (2011) Drosha regulates hMSCs cell cycle progression through a miRNA independent mechanism. Int J Biochem Cell Biol 43:1563-72

Phinney, Donald G; Hill, Katy; Michelson, Charles et al. (2006) Biological activities encoded by the murine mesenchymal stem cell transcriptome provide a basis for their developmental potential and broad therapeutic efficacy. Stem Cells 24:186-98

Spees, Jeffrey L; Gregory, Carl A; Singh, Harpreet et al. (2004) Internalized antigens must be removed to prepare hypoimmunogenic mesenchymal stem cells for cell and gene therapy. Mol Ther 9:747-56

Sekiya, Ichiro; Larson, Benjamin L; Vuoristo, Jussi T et al. (2004) Adipogenic differentiation of human adult stem cells from bone marrow stroma (MSCs). J Bone Miner Res 19:256-64

Prockop, Darwin J; Gregory, Carl A; Spees, Jeffery L (2003) One strategy for cell and gene therapy: harnessing the power of adult stem cells to repair tissues. Proc Natl Acad Sci U S A 100 Suppl 1:11917-23

Sekiya, Ichiro; Vuoristo, Jussi T; Larson, Benjamin L et al. (2002) In vitro cartilage formation by human adult stem cells from bone marrow stroma defines the sequence of cellular and molecular events during chondrogenesis. Proc Natl Acad Sci U S A 99:4397-402

Sekiya, Ichiro; Larson, Benjamin L; Smith, Jason R et al. (2002) Expansion of human adult stem cells from bone marrow stroma: conditions that maximize the yields of early progenitors and evaluate their quality. Stem Cells 20:530-41

Tremain, N; Korkko, J; Ibberson, D et al. (2001) MicroSAGE analysis of 2,353 expressed genes in a single cell-derived colony of undifferentiated human mesenchymal stem cells reveals mRNAs of multiple cell lineages. Stem Cells 19:408-18

Schwarz, E J; Reger, R L; Alexander, G M et al. (2001) Rat marrow stromal cells rapidly transduced with a self-inactivating retrovirus synthesize L-DOPA in vitro. Gene Ther 8:1214-23

Sekiya, I; Colter, D C; Prockop, D J (2001) BMP-6 enhances chondrogenesis in a subpopulation of human marrow stromal cells. Biochem Biophys Res Commun 284:411-8