The long-range goal of this research is to enhance our understanding of how gender is related to the pain experience of individuals having arthritis. Research studies conducted in the laboratory of the principal investigator and elsewhere have shown that women with osteoarthritis (OA) report more intense pain and more severe disability. To date, the basis of this gender difference has been unknown. Preliminary research by the principal investigator suggests that differences in coping may account for gender differences in pain and disability in OA. Three new studies are proposed. Study 1 uses newly developed daily study methods to examine pain, pain coping, and mood as they unfold both within and across days in men and women having knee OA. In this study, 110 patients having knee OA (55 men, 55 women) will keep daily diary records for 30 consecutive days. Each patient will provide two daily diary entries on their pain, pain coping strategies, and mood. This process-oriented research design will permit the examination of: (a) gender differences in the extent and patterning of OA pain and efforts to cope with pain; and (b) how women and men differ in the relations of coping to pain, and mood both within and across days. Studies 2 and 3 will examine the relationship between gender differences in emotion-focused coping and supraspinal modulation of a nocifensive spinal withdrawal reflex known as the nociceptive flexion reflex (NFR). Study 2 will assess the NFR threshold and subjective pain threshold and tolerance levels of 66 men and 66 women having OA knee pain. Study 3 will assess potential gender differences in activation of supraspinal descending pain modulation systems. This study will examine the nociceptive flexion reflex at rest and during a distraction task designed to manipulate attentional focus.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
7R01AR046305-02
Application #
6204024
Study Section
Behavioral Medicine Study Section (BEM)
Program Officer
Serrate-Sztein, Susana
Project Start
1999-09-01
Project End
2003-06-30
Budget Start
1999-10-01
Budget End
2000-06-30
Support Year
2
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Duke University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
Schroeder, David; Korsakov, Fedor; Jolton, Joseph et al. (2013) Creating widely accessible spatial interfaces: mobile VR for managing persistent pain. IEEE Comput Graph Appl 33:82-9
Emery, Charles F; Keefe, Francis J; France, Christopher R et al. (2006) Effects of a brief coping skills training intervention on nociceptive flexion reflex threshold in patients having osteoarthritic knee pain: a preliminary laboratory study of sex differences. J Pain Symptom Manage 31:262-9
Applegate, Katherine L; Keefe, Francis J; Siegler, Ilene C et al. (2005) Does personality at college entry predict number of reported pain conditions at mid-life? A longitudinal study. J Pain 6:92-7
Keefe, Francis J; Abernethy, Amy P; C Campbell, Lisa (2005) Psychological approaches to understanding and treating disease-related pain. Annu Rev Psychol 56:601-30
France, Christopher R; Keefe, Francis J; Emery, Charles F et al. (2004) Laboratory pain perception and clinical pain in post-menopausal women and age-matched men with osteoarthritis: relationship to pain coping and hormonal status. Pain 112:274-81
Smith, Suzanne J A; Keefe, Francis J; Caldwell, David S et al. (2004) Gender differences in patient-spouse interactions: a sequential analysis of behavioral interactions in patients having osteoarthritic knee pain. Pain 112:183-7
McCracken, Lance M; Carson, James W; Eccleston, Christopher et al. (2004) Acceptance and change in the context of chronic pain. Pain 109:4-7
Keefe, Francis J; Rumble, Meredith E; Scipio, Cindy D et al. (2004) Psychological aspects of persistent pain: current state of the science. J Pain 5:195-211
Keefe, Francis J; Affleck, Glenn; France, Christopher R et al. (2004) Gender differences in pain, coping, and mood in individuals having osteoarthritic knee pain: a within-day analysis. Pain 110:571-7
Dominick, Kelli L; Bosworth, Hayden B; Dudley, Tara K et al. (2004) Patterns of opioid analgesic prescription among patients with osteoarthritis. J Pain Palliat Care Pharmacother 18:31-46

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