A variety of modalities, ranging from cartilage transplant to pharmaceuticals, have demonstrated considerable promise as methods for altering the progression of osteoarthritis. This has resulted in heightened interest in methods for assessing early osteoarthritic cartilage changes both in humans and animals. The objective of this proposal is to improve current animal models for the evaluation of therapeutics designed to treat osteoarthritic cartilage. Specifically, the hypothesis of this work is that Optical Coherence Tomography (OCT), when combine with rabbit and rat models of osteoarthritis, will demonstrate unique advantages for the evaluation of potential therapeutics. This program is a continuation of an ongoing collaboration between investigators at Brigham and Women's Hospital and King's College. It is postulated that the proposed model, in addition to increasing information on the efficacy of therapeutics, will reduce the number of animals that need to be sacrificed, the quantity of tissue requiring processing, and the amount of therapeutics required. Furthermore, technological advances can be directly transferred to in vivo human applications. The hypothesis of this proposal will be tested both through technology development and animal studies. The specifics aims are:
Aim 1. To construct a constant velocity polarization rotator for the OCT system.
Aim 2. To development an OCT arthroscope capable of accessing a joint through a 20 gauge needle.
Aim. 3. To validate registration of the arthroscopic based system.
Aim 4. The OCT system will be tested in a rabbit model.
Aim 5. A catheter will be developed to image in a rat model.
Aim 6. The OCT imaging catheter will be tested in a rat model.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR046996-02
Application #
6512254
Study Section
Diagnostic Imaging Study Section (DMG)
Program Officer
Tyree, Bernadette
Project Start
2001-09-15
Project End
2004-05-31
Budget Start
2002-09-01
Budget End
2003-05-31
Support Year
2
Fiscal Year
2002
Total Cost
$182,710
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115
Brezinski, M E (2018) A Quantum Field Approach for Advancing Optical Coherence Tomography Part I: First Order Correlations, Single Photon Interference, and Quantum Noise. J Lasers Opt Photonics 5:
Brezinski, Mark E (2014) Practical Challenges of Current Video Rate OCT Elastography: Accounting for Dynamic and Static Tissue Properties. J Lasers Opt Photonics 1:
Brezinski, Mark E; Harjai, Kishore J (2014) Current OCT Approaches Do Not Reliably Identify TCFAs. J Clin Exp Cardiolog 5:
Brezinski, Mark E; Rupnick, Maria (2014) Can We Advance Macroscopic Quantum Systems Outside the Framework of Complex Decoherence Theory? J Comput Sci Syst Biol 7:119-136
Brezinski, Mark E; Harjai, Kishore J (2014) Longitudinal necrotic shafts near TCFAs--a potential novel mechanism for plaque rupture to trigger ACS? Int J Cardiol 177:738-41
Liu, Bin; Vercollone, Christopher; Brezinski, Mark E (2012) Towards improved collagen assessment: polarization-sensitive optical coherence tomography with tailored reference arm polarization. Int J Biomed Imaging 2012:892680
Brezinski, Mark E (2012) The Advantages of Not Entangling Macroscopic Diamonds at Room Temperature. J At Mol Opt Phys 2012:
Brezinski, Mark E (2011) Current capabilities and challenges for optical coherence tomography as a high-impact cardiovascular imaging modality. Circulation 123:2913-5
Liu, Bin; Azimi, Ehsan; Brezinski, Mark E (2010) Improvement in dynamic range limitation of swept source optical coherence tomography by true logarithmic amplification. J Opt Soc Am A Opt Image Sci Vis 27:404-14
Azimi, Ehsan; Liu, Bin; Brezinski, Mark E (2010) Real-time and high-performance calibration method for high-speed swept-source optical coherence tomography. J Biomed Opt 15:016005

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