- The distinct expression patterns of many members of the phylogenetically conserved homeobox (""""""""HOX"""""""") gene family in both developing and adult skin implicate this group of controller genes in patterning and regenerative processes of the skin. The principal investigator has preliminary data that transgenic mice over-expressing Hoxc13 (GC13 mice) in pre- and postnatal skin exhibit hyperproliferation of follicular and epidermal keratinocytes. These mice exhibit alopecia and a progressive skin defect resembling ichthyosis. This animal model will be used to define the molecular mechanisms underlying these abnormalities, by studying expression of Hoxc13 and its neighbor Hoxc13, screening for differentially expressed mRNAs in skin of normal versus Hoxc13-mutant mouse skin, comparison of Hox12 knockout versus dominant gain-of-function mice, and transcriptional regulation of Hoxc13 and Hoxc12.
| Yu, Ming; Al-Dallal, Salma; Al-Haj, Latifa et al. (2016) Transcriptional regulation of the proto-oncogene Zfp521 by SPI1 (PU.1) and HOXC13. Genesis 54:519-533 |
| Potter, Christopher S; Kern, Michael J; Baybo, Mary Ann et al. (2015) Dysregulated expression of sterol O-acyltransferase 1 (Soat1) in the hair shaft of Hoxc13 null mice. Exp Mol Pathol 99:441-4 |
| Awgulewitsch, Alexander; Majesky, Mark W (2013) Interpreting inflammation: smooth muscle positional identity and nuclear factor-?B signaling. Arterioscler Thromb Vasc Biol 33:1113-5 |
| Fleckman, Philip; Jaeger, Karin; Silva, Kathleen A et al. (2013) Comparative anatomy of mouse and human nail units. Anat Rec (Hoboken) 296:521-32 |
| Sundberg, J P; Silva, K A (2012) What color is the skin of a mouse? Vet Pathol 49:142-5 |
| Webb, C M; Cameron, E M; Sundberg, J P (2012) Fluorescence-labeled reporter gene in transgenic mice provides a useful tool for investigating cutaneous innervation. Vet Pathol 49:727-30 |
| Rice, Robert H; Bradshaw, Katie M; Durbin-Johnson, Blythe P et al. (2012) Differentiating inbred mouse strains from each other and those with single gene mutations using hair proteomics. PLoS One 7:e51956 |
| Potter, Christopher S; Pruett, Nathanael D; Kern, Michael J et al. (2011) The nude mutant gene Foxn1 is a HOXC13 regulatory target during hair follicle and nail differentiation. J Invest Dermatol 131:828-37 |
| Bazzi, Hisham; Demehri, Shadmehr; Potter, Christopher S et al. (2009) Desmoglein 4 is regulated by transcription factors implicated in hair shaft differentiation. Differentiation 78:292-300 |
| Rice, Robert H; Rocke, David M; Tsai, Hua-Sheng et al. (2009) Distinguishing mouse strains by proteomic analysis of pelage hair. J Invest Dermatol 129:2120-5 |
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