Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR047443-03
Application #
6787797
Study Section
Special Emphasis Panel (ZRG1-OBM-2 (01))
Program Officer
Gretz, Elizabeth
Project Start
2002-09-01
Project End
2006-08-31
Budget Start
2004-09-01
Budget End
2005-08-31
Support Year
3
Fiscal Year
2004
Total Cost
$251,685
Indirect Cost
Name
Washington University
Department
Orthopedics
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Darwech, Isra; Otero, Jesse E; Alhawagri, Muhammad A et al. (2010) Tyrosine phosphorylation is required for IkappaB kinase-beta (IKKbeta) activation and function in osteoclastogenesis. J Biol Chem 285:25522-30
Abu-Amer, Yousef (2009) Inflammation, cancer, and bone loss. Curr Opin Pharmacol 9:427-33
Yamanaka, Yasuhiro; Abu-Amer, Wahid; Foglia, Dominica et al. (2008) NFAT2 is an essential mediator of orthopedic particle-induced osteoclastogenesis. J Orthop Res 26:1577-84
Abu-Amer, Yousef; Darwech, Isra; Otero, Jesse (2008) Role of the NF-kappaB axis in immune modulation of osteoclasts and bone loss. Autoimmunity 41:204-11
Abu-Amer, Yousef; Darwech, Isra; Clohisy, John C (2007) Aseptic loosening of total joint replacements: mechanisms underlying osteolysis and potential therapies. Arthritis Res Ther 9 Suppl 1:S6
Yamanaka, Y; Abu-Amer, Y; Faccio, R et al. (2006) Map kinase c-JUN N-terminal kinase mediates PMMA induction of osteoclasts. J Orthop Res 24:1349-57
Clohisy, John C; Yamanaka, Yasuhiro; Faccio, Roberta et al. (2006) Inhibition of IKK activation, through sequestering NEMO, blocks PMMA-induced osteoclastogenesis and calvarial inflammatory osteolysis. J Orthop Res 24:1358-65
Hirayama, Teruhisa; Dai, Simon; Abbas, Sabiha et al. (2005) Inhibition of inflammatory bone erosion by constitutively active STAT-6 through blockade of JNK and NF-kappaB activation. Arthritis Rheum 52:2719-29
Abu-Amer, Yousef (2005) Advances in osteoclast differentiation and function. Curr Drug Targets Immune Endocr Metabol Disord 5:347-55
Dai, Simon; Hirayama, Teruhisa; Abbas, Sabiha et al. (2004) The IkappaB kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks osteoclastogenesis and bone erosion in inflammatory arthritis. J Biol Chem 279:37219-22

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