Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
5R01AR048257-02
Application #
6701383
Study Section
Immunological Sciences Study Section (IMS)
Program Officer
Gretz, Elizabeth
Project Start
2003-01-27
Project End
2007-11-30
Budget Start
2003-12-01
Budget End
2004-11-30
Support Year
2
Fiscal Year
2004
Total Cost
$329,800
Indirect Cost
Name
Children's Hospital of Philadelphia
Department
Type
DUNS #
073757627
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Zhang, Mingce; Ma, Zhengyu; Selliah, Nithianandan et al. (2014) The impact of Nucleofection® on the activation state of primary human CD4 T cells. J Immunol Methods 408:123-31
Lowe, R M; Genin, A; Orgun, N et al. (2014) IL-15 prolongs CD154 expression on human CD4 T cells via STAT5 binding to the CD154 transcriptional promoter. Genes Immun 15:137-44
Mehta, Jay; Genin, Anna; Brunner, Michael et al. (2010) Prolonged expression of CD154 on CD4 T cells from pediatric lupus patients correlates with increased CD154 transcription, increased nuclear factor of activated T cell activity, and glomerulonephritis. Arthritis Rheum 62:2499-509
Torgerson, Troy R; Genin, Anna; Chen, Chunxia et al. (2009) FOXP3 inhibits activation-induced NFAT2 expression in T cells thereby limiting effector cytokine expression. J Immunol 183:907-15
Brunner, M; Zhang, M; Genin, A et al. (2008) A T-cell-specific CD154 transcriptional enhancer located just upstream of the promoter. Genes Immun 9:640-9
Wright, Tracey; Cron, Randy Q (2007) Pediatric rheumatology for the adult rheumatologist II: uveitis in juvenile idiopathic arthritis. J Clin Rheumatol 13:205-10
Yin, Jiyi; Ma, Zhengyu; Selliah, Nithianandan et al. (2006) Effective gene suppression using small interfering RNA in hard-to-transfect human T cells. J Immunol Methods 312:1-11
Cron, Randy Q; Bandyopadhyay, Rupa; Genin, Anna et al. (2006) Early growth response-1 is required for CD154 transcription. J Immunol 176:811-8
Von Feldt, Joan M; Scalzi, Lisabeth V; Cucchiara, Andrew J et al. (2006) Homocysteine levels and disease duration independently correlate with coronary artery calcification in patients with systemic lupus erythematosus. Arthritis Rheum 54:2220-7
DeWitt, Esi M; Sherry, David D; Cron, Randy Q (2005) Pediatric rheumatology for the adult rheumatologist I: therapy and dosing for pediatric rheumatic disorders. J Clin Rheumatol 11:21-33

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